HLA-A2 and Type 2 (insulin independent) diabetes mellitus in Pima Indians

An association of allele frequency with age

R. C. Williams, W. C. Knowler, W. J. Butler, D. J. Pettitt, Jeffrey R Lisse, P. H. Bennett, D. L. Mann, A. H. Johnson, P. I. Terasaki

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In Pima Indians with Type 2 (insulin independent) diabetes mellitus, HLA-A2 allele frequencies were inversely associated with age, (0.72, 0.59, and 0.52 in those less than 35, 35 to 54, and 55 years old and over, respectively). This suggests that there may be a gene closely linked with the HLA-A locus which plays a role in the expression of diabetes in the Pimas by contributing to an earlier age of onset. HLA-A2 was found in 65% of 69 non-diabetic and 81% of 191 diabetic subjects (relative risk = 2.2).

Original languageEnglish (US)
Pages (from-to)460-463
Number of pages4
JournalDiabetologia
Volume21
Issue number5
DOIs
StatePublished - Nov 1981
Externally publishedYes

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HLA-A2 Antigen
Potassium Iodide
Gene Frequency
Diabetes Mellitus
Insulin
HLA-A Antigens
Age of Onset
Genes

Keywords

  • age association
  • diabetes
  • genetics
  • HLA-A2
  • Pima Indians
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Williams, R. C., Knowler, W. C., Butler, W. J., Pettitt, D. J., Lisse, J. R., Bennett, P. H., ... Terasaki, P. I. (1981). HLA-A2 and Type 2 (insulin independent) diabetes mellitus in Pima Indians: An association of allele frequency with age. Diabetologia, 21(5), 460-463. https://doi.org/10.1007/BF00257786

HLA-A2 and Type 2 (insulin independent) diabetes mellitus in Pima Indians : An association of allele frequency with age. / Williams, R. C.; Knowler, W. C.; Butler, W. J.; Pettitt, D. J.; Lisse, Jeffrey R; Bennett, P. H.; Mann, D. L.; Johnson, A. H.; Terasaki, P. I.

In: Diabetologia, Vol. 21, No. 5, 11.1981, p. 460-463.

Research output: Contribution to journalArticle

Williams, RC, Knowler, WC, Butler, WJ, Pettitt, DJ, Lisse, JR, Bennett, PH, Mann, DL, Johnson, AH & Terasaki, PI 1981, 'HLA-A2 and Type 2 (insulin independent) diabetes mellitus in Pima Indians: An association of allele frequency with age', Diabetologia, vol. 21, no. 5, pp. 460-463. https://doi.org/10.1007/BF00257786
Williams, R. C. ; Knowler, W. C. ; Butler, W. J. ; Pettitt, D. J. ; Lisse, Jeffrey R ; Bennett, P. H. ; Mann, D. L. ; Johnson, A. H. ; Terasaki, P. I. / HLA-A2 and Type 2 (insulin independent) diabetes mellitus in Pima Indians : An association of allele frequency with age. In: Diabetologia. 1981 ; Vol. 21, No. 5. pp. 460-463.
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