HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?

Jussara Amato, Thushara W. Madanayake, Nunzia Iaccarino, Ettore Novellino, Antonio Randazzo, Laurence H. Hurley, Bruno Pagano

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.

Original languageEnglish (US)
Pages (from-to)9442-9445
Number of pages4
JournalChemical Communications
Volume54
Issue number68
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Amato, J., Madanayake, T. W., Iaccarino, N., Novellino, E., Randazzo, A., Hurley, L. H., & Pagano, B. (2018). HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation? Chemical Communications, 54(68), 9442-9445. https://doi.org/10.1039/c8cc03614d