HNO Donors: Angeli's Salt and Related Diazeniumdiolates

D. Basudhar, G. Bharadwaj, D. J. Salmon, Katrina M Miranda

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Diazeniumdiolates offer a versatile platform for development of both nitric oxide (NO) and nitroxyl (HNO) donors and have been vital to the study of chemical biology of nitrogen oxides. Derivatization of ionic diazeniumdiolates has been shown to improve the purification process, to dramatically slow the rate of spontaneous decomposition and to provide new therapeutic benefits as a function of addition of bioactive moieties. Decomposition of certain derivatized diazeniumdiolates can also yield acyl nitroso compounds as HNO donors. The breadth of HNO generation profiles from this donor class will allow continued analysis of the pharmacological effects of HNO and may facilitate the search for endogenous HNO. This chapter details the synthesis, structure, and mechanism of decomposition of the widely used HNO donor Angeli's salt as well as related compounds in the diazeniumdiolate class.

Original languageEnglish (US)
Title of host publicationThe Chemistry and Biology of Nitroxyl (HNO)
PublisherElsevier Inc.
Pages11-36
Number of pages26
ISBN (Print)9780128009345
DOIs
StatePublished - Sep 1 2016

Keywords

  • Acyl nitroso compounds
  • Angeli's salt
  • Diazeniumdiolate
  • Nitric oxide
  • Nitroxyl
  • NONOate
  • Prodrug

ASJC Scopus subject areas

  • Chemistry(all)

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    Basudhar, D., Bharadwaj, G., Salmon, D. J., & Miranda, K. M. (2016). HNO Donors: Angeli's Salt and Related Diazeniumdiolates. In The Chemistry and Biology of Nitroxyl (HNO) (pp. 11-36). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800934-5.00002-5