Hold your horses: Impulsivity, deep brain stimulation, and medication in Parkinsonism

Michael J. Frank, Johan Samanta, Ahmed A. Moustafa, Scott J Sherman

Research output: Contribution to journalArticle

676 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. We showed that DBS selectively interferes with the normal ability to slow down when faced with decision conflict. While on DBS, patients actually sped up their decisions under high-conflict conditions. This form of impulsivity was not affected by dopaminergic medication status. Instead, medication impaired patients' ability to learn from negative decision outcomes. These findings implicate independent mechanisms leading to impulsivity in treated Parkinson's patients and were predicted by a single neurocomputational model of the basal ganglia.

Original languageEnglish (US)
Pages (from-to)1309-1312
Number of pages4
JournalScience
Volume318
Issue number5854
DOIs
StatePublished - Nov 23 2007

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Deep Brain Stimulation
Impulsive Behavior
Parkinsonian Disorders
Horses
Aptitude
Subthalamic Nucleus
Basal Ganglia
Parkinson Disease
Conflict (Psychology)

ASJC Scopus subject areas

  • General

Cite this

Hold your horses : Impulsivity, deep brain stimulation, and medication in Parkinsonism. / Frank, Michael J.; Samanta, Johan; Moustafa, Ahmed A.; Sherman, Scott J.

In: Science, Vol. 318, No. 5854, 23.11.2007, p. 1309-1312.

Research output: Contribution to journalArticle

Frank, Michael J. ; Samanta, Johan ; Moustafa, Ahmed A. ; Sherman, Scott J. / Hold your horses : Impulsivity, deep brain stimulation, and medication in Parkinsonism. In: Science. 2007 ; Vol. 318, No. 5854. pp. 1309-1312.
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