Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing

Janko Nikolich-Zugich, J. S. Davies

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Ageing of the innate and adaptive immune system, collectively termed immune senescence, is a complex process. One method to understand the components of ageing involves dissociating the effects of ageing on the cells of the immune system, on the microenvironment in lymphoid organs and tissues where immune cells reside and on the circulating factors that interact with both immune cells and their microenvironment. Heterochronic parabiosis, a surgical union of two organisms of disparate ages, is ideal for this type of study, as it has the power to dissociate the age of the cell and the age of the microenvironment into which the cell resides or is migrating. So far, however, it has been used sparingly to study immune ageing. Here we review the limited literature on homeostatic innate immune cell trafficking in ageing in the absence of chronic inflammation. We also review our own recent data on trafficking of innate immune subsets between primary and secondary lymphoid organs in heterochronic parabiosis. We found no systemic bias in retention or acceptance of neutrophils, macrophages, dendritic cells or natural killer cells with ageing in primary and secondary lymphoid organs. We conclude that these four innate immune cell types migrate to and populate lymphoid organs (peripheral lymph nodes, spleen and bone marrow), regardless of their own age and of the age of lymphoid organs.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalClinical and Experimental Immunology
Volume187
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Parabiosis
Cellular Microenvironment
Cell Aging
Immune System
Lymphoid Tissue
Natural Killer Cells
Dendritic Cells
Neutrophils
Spleen
Lymph Nodes
Bone Marrow
Macrophages
Inflammation

Keywords

  • ageing
  • cell trafficking
  • dendritic cells
  • immunosenescence
  • macrophage
  • natural killer cells
  • spleen and lymph nodes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing. / Nikolich-Zugich, Janko; Davies, J. S.

In: Clinical and Experimental Immunology, Vol. 187, No. 3, 01.03.2017, p. 337-344.

Research output: Contribution to journalReview article

@article{e5298cc81415484a89d545c888524ac1,
title = "Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing",
abstract = "Ageing of the innate and adaptive immune system, collectively termed immune senescence, is a complex process. One method to understand the components of ageing involves dissociating the effects of ageing on the cells of the immune system, on the microenvironment in lymphoid organs and tissues where immune cells reside and on the circulating factors that interact with both immune cells and their microenvironment. Heterochronic parabiosis, a surgical union of two organisms of disparate ages, is ideal for this type of study, as it has the power to dissociate the age of the cell and the age of the microenvironment into which the cell resides or is migrating. So far, however, it has been used sparingly to study immune ageing. Here we review the limited literature on homeostatic innate immune cell trafficking in ageing in the absence of chronic inflammation. We also review our own recent data on trafficking of innate immune subsets between primary and secondary lymphoid organs in heterochronic parabiosis. We found no systemic bias in retention or acceptance of neutrophils, macrophages, dendritic cells or natural killer cells with ageing in primary and secondary lymphoid organs. We conclude that these four innate immune cell types migrate to and populate lymphoid organs (peripheral lymph nodes, spleen and bone marrow), regardless of their own age and of the age of lymphoid organs.",
keywords = "ageing, cell trafficking, dendritic cells, immunosenescence, macrophage, natural killer cells, spleen and lymph nodes",
author = "Janko Nikolich-Zugich and Davies, {J. S.}",
year = "2017",
month = "3",
day = "1",
doi = "10.1111/cei.12920",
language = "English (US)",
volume = "187",
pages = "337--344",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing

AU - Nikolich-Zugich, Janko

AU - Davies, J. S.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Ageing of the innate and adaptive immune system, collectively termed immune senescence, is a complex process. One method to understand the components of ageing involves dissociating the effects of ageing on the cells of the immune system, on the microenvironment in lymphoid organs and tissues where immune cells reside and on the circulating factors that interact with both immune cells and their microenvironment. Heterochronic parabiosis, a surgical union of two organisms of disparate ages, is ideal for this type of study, as it has the power to dissociate the age of the cell and the age of the microenvironment into which the cell resides or is migrating. So far, however, it has been used sparingly to study immune ageing. Here we review the limited literature on homeostatic innate immune cell trafficking in ageing in the absence of chronic inflammation. We also review our own recent data on trafficking of innate immune subsets between primary and secondary lymphoid organs in heterochronic parabiosis. We found no systemic bias in retention or acceptance of neutrophils, macrophages, dendritic cells or natural killer cells with ageing in primary and secondary lymphoid organs. We conclude that these four innate immune cell types migrate to and populate lymphoid organs (peripheral lymph nodes, spleen and bone marrow), regardless of their own age and of the age of lymphoid organs.

AB - Ageing of the innate and adaptive immune system, collectively termed immune senescence, is a complex process. One method to understand the components of ageing involves dissociating the effects of ageing on the cells of the immune system, on the microenvironment in lymphoid organs and tissues where immune cells reside and on the circulating factors that interact with both immune cells and their microenvironment. Heterochronic parabiosis, a surgical union of two organisms of disparate ages, is ideal for this type of study, as it has the power to dissociate the age of the cell and the age of the microenvironment into which the cell resides or is migrating. So far, however, it has been used sparingly to study immune ageing. Here we review the limited literature on homeostatic innate immune cell trafficking in ageing in the absence of chronic inflammation. We also review our own recent data on trafficking of innate immune subsets between primary and secondary lymphoid organs in heterochronic parabiosis. We found no systemic bias in retention or acceptance of neutrophils, macrophages, dendritic cells or natural killer cells with ageing in primary and secondary lymphoid organs. We conclude that these four innate immune cell types migrate to and populate lymphoid organs (peripheral lymph nodes, spleen and bone marrow), regardless of their own age and of the age of lymphoid organs.

KW - ageing

KW - cell trafficking

KW - dendritic cells

KW - immunosenescence

KW - macrophage

KW - natural killer cells

KW - spleen and lymph nodes

UR - http://www.scopus.com/inward/record.url?scp=85011344649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011344649&partnerID=8YFLogxK

U2 - 10.1111/cei.12920

DO - 10.1111/cei.12920

M3 - Review article

VL - 187

SP - 337

EP - 344

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 3

ER -