Homochiral ketals in organic sythesis. Simple chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals

Eugene A. Mash, Susan B. Hemperly

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A general method for the chromatographic resolution of diastereomeric α-hydroxycycloalkanone ketals derived from 1,4-di-O-benzyl-L-threitol is reported. Separability is thought to result from differences in intramolecular hydrogen bonding for the two diastereomeric forms.

Original languageEnglish (US)
Pages (from-to)4035-4038
Number of pages4
JournalTetrahedron Letters
Volume29
Issue number33
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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