Homologous recombination in negative sense RNA viruses

Guan Zhu Han, Michael Worobey

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Recombination is an important process that influences biological evolution at many different levels. More and more homologous recombination events have been reported among negative sense RNA viruses recently. While sporadic authentic examples indicate that homologous recombination does occur, recombination seems to be generally rare or even absent in most negative sense RNA viruses, and most of the homologous recombination events reported in the literature were likely generated artificially due to lab contamination or inappropriate bioinformatics methods. Homologous recombination in negative sense RNA viruses should be reported with caution in the future, and only after stringent quality control efforts. Moreover, co-infection experiments should be performed to confirm whether recombination can occur.

Original languageEnglish (US)
Pages (from-to)1358-1373
Number of pages16
JournalViruses
Volume3
Issue number8
DOIs
StatePublished - Aug 2011

Fingerprint

RNA Viruses
Homologous Recombination
Genetic Recombination
Biological Evolution
Computational Biology
Coinfection
Quality Control

Keywords

  • Evolution
  • Homologous recombination
  • Negative sense RNA viruses

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Homologous recombination in negative sense RNA viruses. / Han, Guan Zhu; Worobey, Michael.

In: Viruses, Vol. 3, No. 8, 08.2011, p. 1358-1373.

Research output: Contribution to journalArticle

Han, Guan Zhu ; Worobey, Michael. / Homologous recombination in negative sense RNA viruses. In: Viruses. 2011 ; Vol. 3, No. 8. pp. 1358-1373.
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