Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia

M. Zhou, L. Gu, C. D. James, J. He, A. M. Yeager, S. D. Smith, H. W. Findley

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene have been found at high frequency in cell lines derived from a variety of adult solid tumors. In order to investigate the status of the CDKN2 gene in cell lines established from childhood acute lymphoblastic leukemia (ALL), we surveyed 25 lines representing the major pediatric ALL phenotypes for the presence of this gene by Southern blot analysis. Homozygous deletions of all or part of the CDKN2 gene were detected in 21 (84%) cell lines, including 11 of 14 (79%) early-pre-B-ALL, four of five (80%) pre-B-ALL, and six of six T-ALL lines. CDKN2 mRNA was detected by Northern blotting in each of the four lines containing an intact CDKN2 gene. These data suggest an important role for CDKN2 deletion in the cause and/or progression of pediatric ALL.

Original languageEnglish (US)
Pages (from-to)1159-1161
Number of pages3
JournalLeukemia
Volume9
Issue number7
StatePublished - Jul 1995

Keywords

  • CDKN2 deletion
  • Pediatric leukemia
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Zhou, M., Gu, L., James, C. D., He, J., Yeager, A. M., Smith, S. D., & Findley, H. W. (1995). Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia. Leukemia, 9(7), 1159-1161.