Human acellular dermal wound matrix

Evidence and experience

Robert S. Kirsner, Greg Bohn, Vickie R. Driver, Joseph L Mills, Lillian B. Nanney, Marie L. Williams, Stephanie C. Wu

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A chronic wound fails to complete an orderly and timely reparative process and places patients at increased risk for wound complications that negatively impact quality of life and require greater health care expenditure. The role of extracellular matrix (ECM) is critical in normal and chronic wound repair. Not only is ECM the largest component of the dermal skin layer, but also ECM proteins provide structure and cell signalling that are necessary for successful tissue repair. Chronic wounds are characterised by their inflammatory and proteolytic environment, which degrades the ECM. Human acellular dermal matrices, which provide an ECM scaffold, therefore, are being used to treat chronic wounds. The ideal human acellular dermal wound matrix (HADWM) would support regenerative healing, providing a structure that could be repopulated by the body's cells. Experienced wound care investigators and clinicians discussed the function of ECM, the evidence related to a specific HADWM (Graftjacket® regenerative tissue matrix, Wright Medical Technology, Inc., licensed by KCI USA, Inc., San Antonio, TX), and their clinical experience with this scaffold. This article distills these discussions into an evidence-based and practical overview for treating chronic lower extremity wounds with this HADWM.

Original languageEnglish (US)
Pages (from-to)646-654
Number of pages9
JournalInternational Wound Journal
Volume12
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Acellular Dermis
Wounds and Injuries
Extracellular Matrix
Skin
Extracellular Matrix Proteins
Health Expenditures
Lower Extremity

Keywords

  • ECM
  • Extracellular matrix
  • Graftjacket RTM
  • Human acellular dermal matrix
  • Regenerative tissue matrix

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

Kirsner, R. S., Bohn, G., Driver, V. R., Mills, J. L., Nanney, L. B., Williams, M. L., & Wu, S. C. (2015). Human acellular dermal wound matrix: Evidence and experience. International Wound Journal, 12(6), 646-654. https://doi.org/10.1111/iwj.12185

Human acellular dermal wound matrix : Evidence and experience. / Kirsner, Robert S.; Bohn, Greg; Driver, Vickie R.; Mills, Joseph L; Nanney, Lillian B.; Williams, Marie L.; Wu, Stephanie C.

In: International Wound Journal, Vol. 12, No. 6, 01.12.2015, p. 646-654.

Research output: Contribution to journalArticle

Kirsner, RS, Bohn, G, Driver, VR, Mills, JL, Nanney, LB, Williams, ML & Wu, SC 2015, 'Human acellular dermal wound matrix: Evidence and experience', International Wound Journal, vol. 12, no. 6, pp. 646-654. https://doi.org/10.1111/iwj.12185
Kirsner RS, Bohn G, Driver VR, Mills JL, Nanney LB, Williams ML et al. Human acellular dermal wound matrix: Evidence and experience. International Wound Journal. 2015 Dec 1;12(6):646-654. https://doi.org/10.1111/iwj.12185
Kirsner, Robert S. ; Bohn, Greg ; Driver, Vickie R. ; Mills, Joseph L ; Nanney, Lillian B. ; Williams, Marie L. ; Wu, Stephanie C. / Human acellular dermal wound matrix : Evidence and experience. In: International Wound Journal. 2015 ; Vol. 12, No. 6. pp. 646-654.
@article{f28d352ee5de482b9d714d4d32c1db3a,
title = "Human acellular dermal wound matrix: Evidence and experience",
abstract = "A chronic wound fails to complete an orderly and timely reparative process and places patients at increased risk for wound complications that negatively impact quality of life and require greater health care expenditure. The role of extracellular matrix (ECM) is critical in normal and chronic wound repair. Not only is ECM the largest component of the dermal skin layer, but also ECM proteins provide structure and cell signalling that are necessary for successful tissue repair. Chronic wounds are characterised by their inflammatory and proteolytic environment, which degrades the ECM. Human acellular dermal matrices, which provide an ECM scaffold, therefore, are being used to treat chronic wounds. The ideal human acellular dermal wound matrix (HADWM) would support regenerative healing, providing a structure that could be repopulated by the body's cells. Experienced wound care investigators and clinicians discussed the function of ECM, the evidence related to a specific HADWM (Graftjacket{\circledR} regenerative tissue matrix, Wright Medical Technology, Inc., licensed by KCI USA, Inc., San Antonio, TX), and their clinical experience with this scaffold. This article distills these discussions into an evidence-based and practical overview for treating chronic lower extremity wounds with this HADWM.",
keywords = "ECM, Extracellular matrix, Graftjacket RTM, Human acellular dermal matrix, Regenerative tissue matrix",
author = "Kirsner, {Robert S.} and Greg Bohn and Driver, {Vickie R.} and Mills, {Joseph L} and Nanney, {Lillian B.} and Williams, {Marie L.} and Wu, {Stephanie C.}",
year = "2015",
month = "12",
day = "1",
doi = "10.1111/iwj.12185",
language = "English (US)",
volume = "12",
pages = "646--654",
journal = "International Wound Journal",
issn = "1742-4801",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Human acellular dermal wound matrix

T2 - Evidence and experience

AU - Kirsner, Robert S.

AU - Bohn, Greg

AU - Driver, Vickie R.

AU - Mills, Joseph L

AU - Nanney, Lillian B.

AU - Williams, Marie L.

AU - Wu, Stephanie C.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - A chronic wound fails to complete an orderly and timely reparative process and places patients at increased risk for wound complications that negatively impact quality of life and require greater health care expenditure. The role of extracellular matrix (ECM) is critical in normal and chronic wound repair. Not only is ECM the largest component of the dermal skin layer, but also ECM proteins provide structure and cell signalling that are necessary for successful tissue repair. Chronic wounds are characterised by their inflammatory and proteolytic environment, which degrades the ECM. Human acellular dermal matrices, which provide an ECM scaffold, therefore, are being used to treat chronic wounds. The ideal human acellular dermal wound matrix (HADWM) would support regenerative healing, providing a structure that could be repopulated by the body's cells. Experienced wound care investigators and clinicians discussed the function of ECM, the evidence related to a specific HADWM (Graftjacket® regenerative tissue matrix, Wright Medical Technology, Inc., licensed by KCI USA, Inc., San Antonio, TX), and their clinical experience with this scaffold. This article distills these discussions into an evidence-based and practical overview for treating chronic lower extremity wounds with this HADWM.

AB - A chronic wound fails to complete an orderly and timely reparative process and places patients at increased risk for wound complications that negatively impact quality of life and require greater health care expenditure. The role of extracellular matrix (ECM) is critical in normal and chronic wound repair. Not only is ECM the largest component of the dermal skin layer, but also ECM proteins provide structure and cell signalling that are necessary for successful tissue repair. Chronic wounds are characterised by their inflammatory and proteolytic environment, which degrades the ECM. Human acellular dermal matrices, which provide an ECM scaffold, therefore, are being used to treat chronic wounds. The ideal human acellular dermal wound matrix (HADWM) would support regenerative healing, providing a structure that could be repopulated by the body's cells. Experienced wound care investigators and clinicians discussed the function of ECM, the evidence related to a specific HADWM (Graftjacket® regenerative tissue matrix, Wright Medical Technology, Inc., licensed by KCI USA, Inc., San Antonio, TX), and their clinical experience with this scaffold. This article distills these discussions into an evidence-based and practical overview for treating chronic lower extremity wounds with this HADWM.

KW - ECM

KW - Extracellular matrix

KW - Graftjacket RTM

KW - Human acellular dermal matrix

KW - Regenerative tissue matrix

UR - http://www.scopus.com/inward/record.url?scp=84946496506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946496506&partnerID=8YFLogxK

U2 - 10.1111/iwj.12185

DO - 10.1111/iwj.12185

M3 - Article

VL - 12

SP - 646

EP - 654

JO - International Wound Journal

JF - International Wound Journal

SN - 1742-4801

IS - 6

ER -