Human and mouse model cognitive phenotypes in Down syndrome: Implications for assessment

Jamie O Edgin, Gina M. Mason, Goffredina Spanò, Andrea Fernández, Lynn Nadel

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The study of cognitive function in Down syndrome (DS) has advanced rapidly in the past decade. Mouse models have generated data regarding the neurological basis for the specific cognitive profile of DS (i.e., deficits in aspects of hippocampal, prefrontal, and cerebellar function) and have uncovered pharmacological treatments with the potential to affect this phenotype. Given this progress, the field is at a juncture in which we require assessments that may effectively translate the findings acquired in mouse models to humans with DS. In this chapter, we describe the cognitive profile of humans with DS and associated mouse models, discussing the ways in which we may merge these findings so as to more fully understand cognitive strengths and weaknesses in this population. New directions for approaches to cognitive assessment in mice and humans are discussed.

Original languageEnglish (US)
Pages (from-to)123-151
Number of pages29
JournalProgress in Brain Research
Volume197
DOIs
StatePublished - 2012

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Down Syndrome
Phenotype
Cognition
Pharmacology
Population

Keywords

  • Cerebellum
  • Cognitive assessment
  • Down syndrome
  • Medial temporal lobe function
  • Mouse models
  • Mouse phenotype
  • Pharmacological intervention
  • Prefrontal function

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Human and mouse model cognitive phenotypes in Down syndrome : Implications for assessment. / Edgin, Jamie O; Mason, Gina M.; Spanò, Goffredina; Fernández, Andrea; Nadel, Lynn.

In: Progress in Brain Research, Vol. 197, 2012, p. 123-151.

Research output: Contribution to journalArticle

Edgin, Jamie O ; Mason, Gina M. ; Spanò, Goffredina ; Fernández, Andrea ; Nadel, Lynn. / Human and mouse model cognitive phenotypes in Down syndrome : Implications for assessment. In: Progress in Brain Research. 2012 ; Vol. 197. pp. 123-151.
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