Human and mouse model cognitive phenotypes in Down syndrome: Implications for assessment

Jamie O. Edgin, Gina M. Mason, Goffredina Spanò, Andrea Fernández, Lynn Nadel

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations

Abstract

The study of cognitive function in Down syndrome (DS) has advanced rapidly in the past decade. Mouse models have generated data regarding the neurological basis for the specific cognitive profile of DS (i.e., deficits in aspects of hippocampal, prefrontal, and cerebellar function) and have uncovered pharmacological treatments with the potential to affect this phenotype. Given this progress, the field is at a juncture in which we require assessments that may effectively translate the findings acquired in mouse models to humans with DS. In this chapter, we describe the cognitive profile of humans with DS and associated mouse models, discussing the ways in which we may merge these findings so as to more fully understand cognitive strengths and weaknesses in this population. New directions for approaches to cognitive assessment in mice and humans are discussed.

Original languageEnglish (US)
Title of host publicationProgress in Brain Research
PublisherElsevier B.V.
Pages123-151
Number of pages29
DOIs
StatePublished - 2012

Publication series

NameProgress in Brain Research
Volume197
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

    Fingerprint

Keywords

  • Cerebellum
  • Cognitive assessment
  • Down syndrome
  • Medial temporal lobe function
  • Mouse models
  • Mouse phenotype
  • Pharmacological intervention
  • Prefrontal function

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Edgin, J. O., Mason, G. M., Spanò, G., Fernández, A., & Nadel, L. (2012). Human and mouse model cognitive phenotypes in Down syndrome: Implications for assessment. In Progress in Brain Research (pp. 123-151). (Progress in Brain Research; Vol. 197). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-54299-1.00007-8