Human EP3I prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression

Tomoko Taniguchi, Hiromichi Fujino, Davelene D. Israel, John W. Regan, Toshihiko Murayama

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A critical event in tumor development is the formation of new blood vessels to provide oxygen, nutrients and growth factors to the rapidly growing cancer cells. This process of angiogenesis is complex, however, it is well established that vascular endothelial growth factor (VEGF)-mediated signaling is an important early event. Knockout mice studies have implicated the EP3 receptor in tumor development and angiogenesis; however, the signaling mechanism involved with this effect is unclear. We now show that stimulation of the EP3I isoform of the human EP3 receptor with prostaglandin E2 increases the mRNA expression of both VEGF and its cognate receptor VEGF receptor-1 (VEGFR-1). These inductions by the EP3I receptor involve the sequential activation of phosphatidylinositol 3-kinase and the extracellular signal-regulated kinases. Up-regulation of VEGF and VEGFR-1 mRNA by the human EP3I receptor has not been previously reported and further strengthen the role of this receptor in tumor-associated angiogenesis.

Original languageEnglish (US)
Pages (from-to)1173-1178
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume377
Issue number4
DOIs
StatePublished - Dec 26 2008

Keywords

  • EP3 receptor
  • PGE
  • VEGF
  • VEGFR-1

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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