Human exposure to dietary inorganic arsenic and other arsenic species: State of knowledge, gaps and uncertainties

Francesco Cubadda, Brian P. Jackson, Kathryn L. Cottingham, Yoshira Ornelas Van Horne, Margaret Kurzius-Spencer

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Inorganic arsenic (iAs) is ubiquitous in the environment as arsenite (AsIII) and arsenate (AsV) compounds and biotransformation of these toxic chemicals leads to the extraordinary variety of organoarsenic species found in nature. Despite classification as a human carcinogen based on data from populations exposed through contaminated drinking water, only recently has a need for regulatory limits on iAs in food been recognized. The delay was due to the difficulty in risk assessment of dietary iAs, which critically relies on speciation analysis providing occurrence data for iAs in food – and not simply for total arsenic. In the present review the state of knowledge regarding arsenic speciation in food and diet is evaluated with focus on iAs and human exposure assessment through different dietary approaches including duplicate diet studies, market basket surveys, and total diet studies. The analytical requirements for obtaining reliable data for iAs in food are discussed and iAs levels in foods and beverages are summarized, along with information on other (potentially) toxic co-occurring organoarsenic compounds. Quantitative exposure assessment of iAs in food is addressed, focusing on the need of capturing variability and extent of exposure and identifying what dietary items drive very high exposure for certain population groups. Finally, gaps and uncertainties are discussed, including effect of processing and cooking, and iAs bioavailability.

Original languageEnglish (US)
Pages (from-to)1228-1239
Number of pages12
JournalScience of the Total Environment
Volume579
DOIs
StatePublished - Feb 1 2017

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Arsenic
arsenic
food
Nutrition
Poisons
diet
Uncertainty
exposure
Carcinogens
Beverages
arsenite
Cooking
carcinogen
biotransformation
arsenate
Potable water
Drinking Water
Risk assessment
bioavailability
risk assessment

Keywords

  • Arsenic speciation
  • Dietary exposure
  • Food
  • Human health
  • Inorganic arsenic
  • Risk assessment

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

Cite this

Human exposure to dietary inorganic arsenic and other arsenic species : State of knowledge, gaps and uncertainties. / Cubadda, Francesco; Jackson, Brian P.; Cottingham, Kathryn L.; Van Horne, Yoshira Ornelas; Kurzius-Spencer, Margaret.

In: Science of the Total Environment, Vol. 579, 01.02.2017, p. 1228-1239.

Research output: Contribution to journalArticle

Cubadda, Francesco ; Jackson, Brian P. ; Cottingham, Kathryn L. ; Van Horne, Yoshira Ornelas ; Kurzius-Spencer, Margaret. / Human exposure to dietary inorganic arsenic and other arsenic species : State of knowledge, gaps and uncertainties. In: Science of the Total Environment. 2017 ; Vol. 579. pp. 1228-1239.
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