Human immune response to a xenogeneic nucleated cell

Jules E. Harris, Evan M Hersh, Sara Huggins

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Four normal human subjects were immunized with alligator erythrocytes. The development of in vitro lymphocyte blastogenesis and humoral antibody to these cells was followed at serial intervals after immunization. Humoral antibody was not detected in preimmunization samples of serum. Significant in vitro lymphocyte blastogenesis to alligator erythrocytes was seen with all four subjects prior to immunization. This reaction represented either a primary immune response in vitro or an example of antigenic cross reactivity. Following immunization, there was a rapid increase in the blastogenic response. This effect was noted before antibody was detected in the serum and persisted long after antibody could no longer be measured. There was, however, a correlation between antibody formation and in vitro lymphocyte blastogenesis. It is concluded that in vitro lymphocyte blastogenesis is a more sensitive index for both the development and the persistence of an immune response to a xenogeneic cell than is the measurement of humoral antibody.

Original languageEnglish (US)
Pages (from-to)440-446
Number of pages7
JournalTransplantation
Volume9
Issue number5
StatePublished - 1970
Externally publishedYes

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Lymphocyte Activation
Antibodies
Lymphocytes
Alligators and Crocodiles
Immunization
Erythrocytes
Serum
Antibody Formation
In Vitro Techniques

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Harris, J. E., Hersh, E. M., & Huggins, S. (1970). Human immune response to a xenogeneic nucleated cell. Transplantation, 9(5), 440-446.

Human immune response to a xenogeneic nucleated cell. / Harris, Jules E.; Hersh, Evan M; Huggins, Sara.

In: Transplantation, Vol. 9, No. 5, 1970, p. 440-446.

Research output: Contribution to journalArticle

Harris, JE, Hersh, EM & Huggins, S 1970, 'Human immune response to a xenogeneic nucleated cell', Transplantation, vol. 9, no. 5, pp. 440-446.
Harris, Jules E. ; Hersh, Evan M ; Huggins, Sara. / Human immune response to a xenogeneic nucleated cell. In: Transplantation. 1970 ; Vol. 9, No. 5. pp. 440-446.
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