Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

Vesna Pulko, John S. Davies, Carmine Martinez, Marion C. Lanteri, Michael P. Busch, Michael S. Diamond, Kenneth S Knox, Erin C. Bush, Peter A. Sims, Shripad Sinari, David D Billheimer, Elias K. Haddad, Kristy O. Murray, Anne M Wertheimer, Janko Nikolich-Zugich

Research output: Contribution to journalArticle

59 Scopus citations


The number of naive T cells decreases and susceptibility to new microbial infections increases with age. Here we describe a previously unknown subset of phenotypically naive human CD8+ T cells that rapidly secreted multiple cytokines in response to persistent viral antigens but differed transcriptionally from memory and effector T cells. The frequency of these CD8+ T cells, called 'memory T cells with a naive phenotype' (TMNP cells), increased with age and after severe acute infection and inversely correlated with the residual capacity of the immune system to respond to new infections with age. CD8+ T MNP cells represent a potential new target for the immunotherapy of persistent infections and should be accounted for and subtracted from the naive pool if truly naive T cells are needed to respond to antigens.

Original languageEnglish (US)
Pages (from-to)966-975
Number of pages10
JournalNature Immunology
Issue number8
Publication statusPublished - Jul 19 2016


ASJC Scopus subject areas

  • Immunology

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