Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

Vesna Pulko, John S. Davies, Carmine Martinez, Marion C. Lanteri, Michael P. Busch, Michael S. Diamond, Kenneth Knox, Erin C. Bush, Peter A. Sims, Shripad Sinari, Dean Billheimer, Elias K. Haddad, Kristy O. Murray, Anne M. Wertheimer, Janko Nikolich-Žugich

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

The number of naive T cells decreases and susceptibility to new microbial infections increases with age. Here we describe a previously unknown subset of phenotypically naive human CD8+ T cells that rapidly secreted multiple cytokines in response to persistent viral antigens but differed transcriptionally from memory and effector T cells. The frequency of these CD8+ T cells, called 'memory T cells with a naive phenotype' (TMNP cells), increased with age and after severe acute infection and inversely correlated with the residual capacity of the immune system to respond to new infections with age. CD8+ T MNP cells represent a potential new target for the immunotherapy of persistent infections and should be accounted for and subtracted from the naive pool if truly naive T cells are needed to respond to antigens.

Original languageEnglish (US)
Pages (from-to)966-975
Number of pages10
JournalNature immunology
Volume17
Issue number8
DOIs
StatePublished - Jul 19 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Pulko, V., Davies, J. S., Martinez, C., Lanteri, M. C., Busch, M. P., Diamond, M. S., Knox, K., Bush, E. C., Sims, P. A., Sinari, S., Billheimer, D., Haddad, E. K., Murray, K. O., Wertheimer, A. M., & Nikolich-Žugich, J. (2016). Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses. Nature immunology, 17(8), 966-975. https://doi.org/10.1038/ni.3483