Human papillomavirus prevalence and type distribution in male anogenital sites and semen

Carrie M. Nielson, Roberto Flores, Robin B Harris, Martha Abrahamsen, Mary R. Papenfuss, Eileen F. Dunne, Lauri E. Markowitz, Anna R. Giuliano

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Background: Human papillomavirus (HPV) is sexually transmitted and causes cervical cancer. Although HPV can infect men and women, little is known about infection in men. Specifically, the prevalence of type-specific HPV infection and the distribution of infections by anogenital anatomic site in men are incompletely characterized. Methods: We tested 463 men ages 18 to 40 years for HPV at the glans/corona, penile shaft, scrotum, urethra, perianal area, anal canal, and in a semen sample. Eligible men acknowledged no history of genital warts and had sexual intercourse with a woman within the past year. HPV testing by PCR and reverse line blot genotyping for 37 types was conducted on each of the specimens from the seven sampling sites. Results: When HPV results from any sampling site were considered, 237 (51.2%) men were positive for at least one oncogenic or nononcogenic HPV type, and another 66 (14.3%) men were positive for an unclassified HPV type. The types with the highest prevalence were HPV-16 (11.4%) and 84 (10.6%). External genital samples (glans/corona, shaft, and scrotum) were more likely than anal samples to contain oncogenic HPV (25.1% versus 5.0%). HPV-positive penile shaft and glans/corona samples were also more likely to be infected with multiple HPV types than other sites. Conclusions: More complete anogenital sampling and sensitive detection for 37 HPV types resulted in a higher HPV prevalence in primarily asymptomatic men than reported previously. The penile shaft was the site most likely to be HPV positive and harbored the greatest proportion of multiple type and oncogenic infections. These results have implications for research of HPV among men and transmission between partners.

Original languageEnglish (US)
Pages (from-to)1107-1114
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume16
Issue number6
DOIs
StatePublished - Jun 1 2007

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Semen
Scrotum
Infection
Condylomata Acuminata
Papillomavirus Infections
Human papillomavirus 16
Coitus
Anal Canal
Urethra
Uterine Cervical Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Human papillomavirus prevalence and type distribution in male anogenital sites and semen. / Nielson, Carrie M.; Flores, Roberto; Harris, Robin B; Abrahamsen, Martha; Papenfuss, Mary R.; Dunne, Eileen F.; Markowitz, Lauri E.; Giuliano, Anna R.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 16, No. 6, 01.06.2007, p. 1107-1114.

Research output: Contribution to journalArticle

Nielson, CM, Flores, R, Harris, RB, Abrahamsen, M, Papenfuss, MR, Dunne, EF, Markowitz, LE & Giuliano, AR 2007, 'Human papillomavirus prevalence and type distribution in male anogenital sites and semen', Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 6, pp. 1107-1114. https://doi.org/10.1158/1055-9965.EPI-06-0997
Nielson, Carrie M. ; Flores, Roberto ; Harris, Robin B ; Abrahamsen, Martha ; Papenfuss, Mary R. ; Dunne, Eileen F. ; Markowitz, Lauri E. ; Giuliano, Anna R. / Human papillomavirus prevalence and type distribution in male anogenital sites and semen. In: Cancer Epidemiology Biomarkers and Prevention. 2007 ; Vol. 16, No. 6. pp. 1107-1114.
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abstract = "Background: Human papillomavirus (HPV) is sexually transmitted and causes cervical cancer. Although HPV can infect men and women, little is known about infection in men. Specifically, the prevalence of type-specific HPV infection and the distribution of infections by anogenital anatomic site in men are incompletely characterized. Methods: We tested 463 men ages 18 to 40 years for HPV at the glans/corona, penile shaft, scrotum, urethra, perianal area, anal canal, and in a semen sample. Eligible men acknowledged no history of genital warts and had sexual intercourse with a woman within the past year. HPV testing by PCR and reverse line blot genotyping for 37 types was conducted on each of the specimens from the seven sampling sites. Results: When HPV results from any sampling site were considered, 237 (51.2{\%}) men were positive for at least one oncogenic or nononcogenic HPV type, and another 66 (14.3{\%}) men were positive for an unclassified HPV type. The types with the highest prevalence were HPV-16 (11.4{\%}) and 84 (10.6{\%}). External genital samples (glans/corona, shaft, and scrotum) were more likely than anal samples to contain oncogenic HPV (25.1{\%} versus 5.0{\%}). HPV-positive penile shaft and glans/corona samples were also more likely to be infected with multiple HPV types than other sites. Conclusions: More complete anogenital sampling and sensitive detection for 37 HPV types resulted in a higher HPV prevalence in primarily asymptomatic men than reported previously. The penile shaft was the site most likely to be HPV positive and harbored the greatest proportion of multiple type and oncogenic infections. These results have implications for research of HPV among men and transmission between partners.",
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T1 - Human papillomavirus prevalence and type distribution in male anogenital sites and semen

AU - Nielson, Carrie M.

AU - Flores, Roberto

AU - Harris, Robin B

AU - Abrahamsen, Martha

AU - Papenfuss, Mary R.

AU - Dunne, Eileen F.

AU - Markowitz, Lauri E.

AU - Giuliano, Anna R.

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N2 - Background: Human papillomavirus (HPV) is sexually transmitted and causes cervical cancer. Although HPV can infect men and women, little is known about infection in men. Specifically, the prevalence of type-specific HPV infection and the distribution of infections by anogenital anatomic site in men are incompletely characterized. Methods: We tested 463 men ages 18 to 40 years for HPV at the glans/corona, penile shaft, scrotum, urethra, perianal area, anal canal, and in a semen sample. Eligible men acknowledged no history of genital warts and had sexual intercourse with a woman within the past year. HPV testing by PCR and reverse line blot genotyping for 37 types was conducted on each of the specimens from the seven sampling sites. Results: When HPV results from any sampling site were considered, 237 (51.2%) men were positive for at least one oncogenic or nononcogenic HPV type, and another 66 (14.3%) men were positive for an unclassified HPV type. The types with the highest prevalence were HPV-16 (11.4%) and 84 (10.6%). External genital samples (glans/corona, shaft, and scrotum) were more likely than anal samples to contain oncogenic HPV (25.1% versus 5.0%). HPV-positive penile shaft and glans/corona samples were also more likely to be infected with multiple HPV types than other sites. Conclusions: More complete anogenital sampling and sensitive detection for 37 HPV types resulted in a higher HPV prevalence in primarily asymptomatic men than reported previously. The penile shaft was the site most likely to be HPV positive and harbored the greatest proportion of multiple type and oncogenic infections. These results have implications for research of HPV among men and transmission between partners.

AB - Background: Human papillomavirus (HPV) is sexually transmitted and causes cervical cancer. Although HPV can infect men and women, little is known about infection in men. Specifically, the prevalence of type-specific HPV infection and the distribution of infections by anogenital anatomic site in men are incompletely characterized. Methods: We tested 463 men ages 18 to 40 years for HPV at the glans/corona, penile shaft, scrotum, urethra, perianal area, anal canal, and in a semen sample. Eligible men acknowledged no history of genital warts and had sexual intercourse with a woman within the past year. HPV testing by PCR and reverse line blot genotyping for 37 types was conducted on each of the specimens from the seven sampling sites. Results: When HPV results from any sampling site were considered, 237 (51.2%) men were positive for at least one oncogenic or nononcogenic HPV type, and another 66 (14.3%) men were positive for an unclassified HPV type. The types with the highest prevalence were HPV-16 (11.4%) and 84 (10.6%). External genital samples (glans/corona, shaft, and scrotum) were more likely than anal samples to contain oncogenic HPV (25.1% versus 5.0%). HPV-positive penile shaft and glans/corona samples were also more likely to be infected with multiple HPV types than other sites. Conclusions: More complete anogenital sampling and sensitive detection for 37 HPV types resulted in a higher HPV prevalence in primarily asymptomatic men than reported previously. The penile shaft was the site most likely to be HPV positive and harbored the greatest proportion of multiple type and oncogenic infections. These results have implications for research of HPV among men and transmission between partners.

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