Human papillomavirus type 16 does not require cathepsin L or B for infection

Christine M. Calton, Angela M. Schlegel, Janice A. Chapman, Samuel K. Campos

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Cathepsin L (CatL) and cathepsin B (CatB) are lysosomal proteases that many viruses utilize for capsid disassembly. We tested whether CatL and CatB are required for infection by human papillomavirus type 16 (HPV16). CatL and CatB-deficient mouse embryonic fibroblasts had higher levels of infection when compared with wild-type cells. Similar results were obtained in HaCaT keratinocytes treated with CatL or CatB-specific small interfering RNA. Thus, CatL and CatB are not required for HPV16 infection but instead appear to restrict infection.

Original languageEnglish (US)
Pages (from-to)1865-1869
Number of pages5
JournalJournal of General Virology
Volume94
Issue numberPART8
DOIs
StatePublished - Aug 1 2013

ASJC Scopus subject areas

  • Virology

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