Human telomeric G-quadruplex structures and G-quadruplex-interactive compounds

Clement Lin, Danzhou Yang

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. It has been shown that the 3′ G-rich single-stranded overhangs of human telomeres can form G-quadruplex structures, and the human telomeric DNA G-quadruplexes are considered attractive targets for anticancer drugs. G-quadruplex-interactive compounds have been shown to inhibit telomerase access as well as telomere capping. Nuclear magnetic resonance (NMR) spectroscopy is a powerful method in determining the G-quadruplex structures under physiologically relevant conditions. We present the NMR and biophysical methodology used in our research group for the study of G-quadruplex structures in physiologically relevant solution and their interactions with small-molecule compounds.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages171-196
Number of pages26
Volume1587
DOIs
StatePublished - 2017
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1587
ISSN (Print)10643745

Keywords

  • Anticancer drug targets
  • G-Quadruplex structures
  • G-Quadruplex-interactive compounds
  • Human telomeres
  • Structure polymorphism
  • Telomerase inhibitors

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Human telomeric G-quadruplex structures and G-quadruplex-interactive compounds'. Together they form a unique fingerprint.

Cite this