HuMiX: A microfluidics-based in vitro co-culture device for investigating host-microbe molecular interactions

Pranjul Shah, Joelle Fritz, Matt Estes, Frederic Zenhausern, Paul Wilmes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lack of in vitro co-culture devices hinder investigations aiming to uncover the role of human-associated microbial community imbalances in causation of numerous medical conditions. We describe the development and validation of a microfluidics-based co-culture device (HuMiX) allowing co-cultivation of human and microbial cells. The modular device architecture provides access to individual co-cultured contingents following targeted perturbations which facilitate high resolution systemic investigations into the hypothesized role of the complex host-microbial molecular interactions in the pathogenesis of idiopathic medical conditions.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages300-302
Number of pages3
ISBN (Print)9780979806476
StatePublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

Keywords

  • Co-culture
  • Gut on chip
  • Host-Microbe interaction
  • Microbiome
  • Organs on chip

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Shah, P., Fritz, J., Estes, M., Zenhausern, F., & Wilmes, P. (2014). HuMiX: A microfluidics-based in vitro co-culture device for investigating host-microbe molecular interactions. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 300-302). Chemical and Biological Microsystems Society.