Hydrolysis and protein binding of melphalan

S. Y. Chang, D. S. Alberts, D. Farquhar, L. R. Melnick, P. D. Walson, S. E. Salmon

Research output: Contribution to journalArticle

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Abstract

Melphalan (30 μg/ml) is completely hydrolyzed in water at 37° after 8 hr. At lower temperatures, hydrolysis proceeds at slower rates. The presence of bovine serum albumin retards hydrolysis of melphalan (30 μg/ml) in water. The melphalan hydrolysis rate is directly related to the bovine serum albumin concentration. At 37° 8 g of bovine serum albumin/100 ml of water gives a recovery rate of melphalan similar to that of human plasma. In vitro alkylation of melphalan at 37° with human plasma containing 30 μg/ml, calculated by equilibrium dialysis, methanol extraction, and high‐pressure liquid chromatographic analysis, is 30% after 8 hr.

Original languageEnglish (US)
Pages (from-to)682-684
Number of pages3
JournalJournal of pharmaceutical sciences
Volume67
Issue number5
DOIs
StatePublished - May 1978

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Keywords

  • Antineoplastic agents—melphalan, hydrolysis, effect of bovine serum albumin, various temperatures
  • Hydrolysis—melphalan, effect of bovine serum albumin, various temperatures
  • Melphalan—hydrolysis, effect of bovine serum albumin, various temperatures

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Chang, S. Y., Alberts, D. S., Farquhar, D., Melnick, L. R., Walson, P. D., & Salmon, S. E. (1978). Hydrolysis and protein binding of melphalan. Journal of pharmaceutical sciences, 67(5), 682-684. https://doi.org/10.1002/jps.2600670530