Hydrolysis and protein binding of melphalan

S. Y. Chang, D. S. Alberts, D. Farquhar, L. R. Melnick, P. D. Walson, S. E. Salmon

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Melphalan (30 μg/ml) is completely hydrolyzed in water at 37° after 8 hr. At lower temperatures, hydrolysis proceeds at slower rates. The presence of bovine serum albumin retards hydrolysis of melphalan (30 μg/ml) in water. The melphalan hydrolysis rate is directly related to the bovine serum albumin concentration. At 37° 8 g of bovine serum albumin/100 ml of water gives a recovery rate of melphalan similar to that of human plasma. In vitro alkylation of melphalan at 37° with human plasma containing 30 μg/ml, calculated by equilibrium dialysis, methanol extraction, and high‐pressure liquid chromatographic analysis, is 30% after 8 hr.

Original languageEnglish (US)
Pages (from-to)682-684
Number of pages3
JournalJournal of pharmaceutical sciences
Issue number5
StatePublished - May 1978


  • Antineoplastic agents—melphalan, hydrolysis, effect of bovine serum albumin, various temperatures
  • Hydrolysis—melphalan, effect of bovine serum albumin, various temperatures
  • Melphalan—hydrolysis, effect of bovine serum albumin, various temperatures

ASJC Scopus subject areas

  • Pharmaceutical Science


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