Hypercapnic acidosis attenuates pressure-dependent increase in whole-lung filtration coefficient (Kf)

Nikhil Bommakanti, Ayman Isbatan, Avni Bavishi, Gourisree Dharmavaram, Andreia Z. Chignalia, Randal O. Dull

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hypercapnic acidosis (HCA) has beneficial effects in experimental models of lung injury by attenuating inflammation and decreasing pulmonary edema. However, HCA increases pulmonary vascular pressure that will increase fluid filtration and worsen edema development. To reconcile these disparate effects, we tested the hypothesis that HCA inhibits endothelial mechanotransduction and protects against pressure-dependent increases in the whole lung filtration coefficient (Kf). Isolated perfused rat lung preparation was used to measure whole lung filtration coefficient (Kf) at two levels of left atrial pressure (PLA=7.5 versus 15 cm H2O) and at low tidal volume (LVt) versus standard tidal volume (STVt) ventilation. The ratio of Kf2/Kf1 was used as the index of whole lung permeability. Double occlusion pressure, pulmonary artery pressure, pulmonary capillary pressures, and zonal characteristics (ZC) were measured to assess effects of HCA on hemodynamics and their relationship to Kf2/Kf1. An increase in PLA2 from 7.5 to 15 cm H2O resulted in a 4.9-fold increase in Kf2/Kf1 during LVt and a 4.8-fold increase during STVt. During LVt, HCA reduced Kf2/Kf1 by 2.7-fold and reduced STVt Kf2/Kf1 by 5.2-fold. Analysis of pulmonary hemodynamics revealed no significant differences in filtration forces in response to HCA. HCA interferes with lung vascular mechanotransduction and prevents pressure-dependent increases in whole lung filtration coefficient. These results contribute to a further understanding of the lung protective effects of HCA.

Original languageEnglish (US)
Pages (from-to)719-726
Number of pages8
JournalPulmonary Circulation
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Acidosis
Pressure
Lung
Tidal Volume
Blood Vessels
Hemodynamics
Atrial Pressure
Lung Injury
Pulmonary Edema
Pulmonary Artery
Ventilation
Permeability
Edema
Theoretical Models
Inflammation

Keywords

  • Filtration coefficient
  • Hypercapnic acidosis
  • Mechanotransduction
  • Pulmonary edema
  • Rat

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Hypercapnic acidosis attenuates pressure-dependent increase in whole-lung filtration coefficient (Kf). / Bommakanti, Nikhil; Isbatan, Ayman; Bavishi, Avni; Dharmavaram, Gourisree; Chignalia, Andreia Z.; Dull, Randal O.

In: Pulmonary Circulation, Vol. 7, No. 3, 01.01.2017, p. 719-726.

Research output: Contribution to journalArticle

Bommakanti, Nikhil ; Isbatan, Ayman ; Bavishi, Avni ; Dharmavaram, Gourisree ; Chignalia, Andreia Z. ; Dull, Randal O. / Hypercapnic acidosis attenuates pressure-dependent increase in whole-lung filtration coefficient (Kf). In: Pulmonary Circulation. 2017 ; Vol. 7, No. 3. pp. 719-726.
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