Hyperimmune bovine colostrum neutralizes Cryptosporidium sporozoites and protects mice against oocyst challenge

R. Fayer, L. E. Perryman, Michael W Riggs

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Activity of colostral whey, produced by a cow immunized with oocysts of Cryptosporidium parvum and found to provide prophylaxis against cryptosporidiosis in calves, was tested in 2 experiments. In one experiment BALB/c mice were given the immune whey (HW), whey from a nonimmunized cow (CW), or a balanced salt solution (HBSS) before, during, and after oral inoculation with oocysts of C. parvum. Significantly fewer (P < 0.05) C. parvum were found in mice that received HW (undiluted, 1:20 or 1:50) than in those treated with similarly diluted CW or with HBSS. In the second experiment it was determined that protection was mediated by specific anti-sporozoite activity when significantly fewer (P < 0.05) C. parvum were found in mice that received sporozoites treated with HW diluted 1:20 or 1:50 compared with mice that received sporozoites treated with similarly diluted CW or with HBSS.

Original languageEnglish (US)
Pages (from-to)151-153
Number of pages3
JournalJournal of Parasitology
Volume75
Issue number1
StatePublished - 1989
Externally publishedYes

Fingerprint

Cryptosporidium parvum
cow colostrum
Sporozoites
Cryptosporidium
Colostrum
Oocysts
sporozoites
oocysts
whey
cows
mice
experiment
Cryptosporidiosis
cryptosporidiosis
inoculation
oral administration
salt
disease control
Salts
calves

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Microbiology
  • Parasitology

Cite this

Hyperimmune bovine colostrum neutralizes Cryptosporidium sporozoites and protects mice against oocyst challenge. / Fayer, R.; Perryman, L. E.; Riggs, Michael W.

In: Journal of Parasitology, Vol. 75, No. 1, 1989, p. 151-153.

Research output: Contribution to journalArticle

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