Hyperpolarized 129Xe MR imaging of alveolar gas uptake in humans

Zackary I. Cleveland, Gary P. Cofer, Gregory Metz, Denise Beaver, John Nouls, S. Sivaram Kaushik, Monica Kraft, Jan Wolber, Kevin T. Kelly, H. Page Mcadams, Bastiaan Driehuys

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Background: One of the central physiological functions of the lungs is to transfer inhaled gases from the alveoli to pulmonary capillary blood. However, current measures of alveolar gas uptake provide only global information and thus lack the sensitivity and specificity needed to account for regional variations in gas exchange. Methods and Principal Findings: Here we exploit the solubility, high magnetic resonance (MR) signal intensity, and large chemical shift of hyperpolarized (HP) 129Xe to probe the regional uptake of alveolar gases by directly imaging HP 129Xe dissolved in the gas exchange tissues and pulmonary capillary blood of human subjects. The resulting single breath-hold, three-dimensional MR images are optimized using millisecond repetition times and high flip angle radio-frequency pulses, because the dissolved HP 129Xe magnetization is rapidly replenished by diffusive exchange with alveolar 129Xe. The dissolved HP 129Xe MR images display significant, directional heterogeneity, with increased signal intensity observed from the gravity-dependent portions of the lungs. Conclusions: The features observed in dissolved-phase 129Xe MR images are consistent with gravity-dependent lung deformation, which produces increased ventilation, reduced alveolar size (i.e., higher surface-to-volume ratios), higher tissue densities, and increased perfusion in the dependent portions of the lungs. Thus, these results suggest that dissolved HP 129Xe imaging reports on pulmonary function at a fundamental level.

Original languageEnglish (US)
Article numbere12192
JournalPloS one
Volume5
Issue number8
DOIs
StatePublished - Oct 19 2010
Externally publishedYes

Fingerprint

Magnetic resonance
magnetic resonance imaging
Gases
lungs
Magnetic Resonance Imaging
gases
uptake mechanisms
Imaging techniques
Magnetic Resonance Spectroscopy
Lung
pulmonary gas exchange
blood capillaries
lung function
Gravitation
gravity
Blood
Pulmonary Alveoli
image analysis
dissolved gases
Tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Cleveland, Z. I., Cofer, G. P., Metz, G., Beaver, D., Nouls, J., Kaushik, S. S., ... Driehuys, B. (2010). Hyperpolarized 129Xe MR imaging of alveolar gas uptake in humans. PloS one, 5(8), [e12192]. https://doi.org/10.1371/journal.pone.0012192

Hyperpolarized 129Xe MR imaging of alveolar gas uptake in humans. / Cleveland, Zackary I.; Cofer, Gary P.; Metz, Gregory; Beaver, Denise; Nouls, John; Kaushik, S. Sivaram; Kraft, Monica; Wolber, Jan; Kelly, Kevin T.; Mcadams, H. Page; Driehuys, Bastiaan.

In: PloS one, Vol. 5, No. 8, e12192, 19.10.2010.

Research output: Contribution to journalArticle

Cleveland, ZI, Cofer, GP, Metz, G, Beaver, D, Nouls, J, Kaushik, SS, Kraft, M, Wolber, J, Kelly, KT, Mcadams, HP & Driehuys, B 2010, 'Hyperpolarized 129Xe MR imaging of alveolar gas uptake in humans', PloS one, vol. 5, no. 8, e12192. https://doi.org/10.1371/journal.pone.0012192
Cleveland ZI, Cofer GP, Metz G, Beaver D, Nouls J, Kaushik SS et al. Hyperpolarized 129Xe MR imaging of alveolar gas uptake in humans. PloS one. 2010 Oct 19;5(8). e12192. https://doi.org/10.1371/journal.pone.0012192
Cleveland, Zackary I. ; Cofer, Gary P. ; Metz, Gregory ; Beaver, Denise ; Nouls, John ; Kaushik, S. Sivaram ; Kraft, Monica ; Wolber, Jan ; Kelly, Kevin T. ; Mcadams, H. Page ; Driehuys, Bastiaan. / Hyperpolarized 129Xe MR imaging of alveolar gas uptake in humans. In: PloS one. 2010 ; Vol. 5, No. 8.
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