Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells

Itaru Sato, Masanari Umemura, Kenji Mitsudo, Mitomu Kioi, Hideyuki Nakashima, Toshinori Iwai, Xianfeng Feng, Kayoko Oda, Akiyoshi Miyajima, Ayako Makino, Maki Iwai, Takayuki Fujita, Utako Yokoyama, Satoshi Okumura, Motohiko Sato, Haruki Eguchi, Iwai Tohnai, Yoshihiro Ishikawa

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Hyperthermia is a promising anti-cancer treatment in which the tissue temperature is increased to 42-45 °C, and which is often used in combination with chemotherapy or radiation therapy. Our aim in the present work was to examine the feasibility of combination therapy for oral cancer with cisplatin and hyperthermia generated with ferucarbotran (Resovist®; superparamagnetic iron oxide) in an alternating magnetic field (AMF). First, we established that administration of ferucarbotran at the approved dosage for magnetic resonance imaging provides an iron concentration sufficient to increase the temperature to 42.5 °C upon exposure to AMF. Then, we examined the effect of cisplatin combined with ferucarbotran/AMF-induced hyperthermia on cultured human oral cancer cells (HSC-3 and OSC-19). Cisplatin alone induced apoptosis of cancer cells in a dose-dependent manner, as is well known. However, the combination of cisplatin with ferucarbotran/AMF was significantly more effective than cisplatin alone. This result suggests that it might be possible to reduce the clinically effective dosage of cisplatin by administering it in combination with ferucarbotran/AMF-induced hyperthermia, thereby potentially reducing the incidence of serious cisplatin-related side effects. Further work seems justified to evaluate simultaneous thermo-chemotherapy as a new approach to anticancer therapy.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalJournal of Physiological Sciences
Volume64
Issue number3
DOIs
StatePublished - May 2014

Keywords

  • Anti-cancer effect
  • Cisplatin
  • Ferucarbotran
  • Hyperthermia
  • Oral cancer
  • Resovist®

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells'. Together they form a unique fingerprint.

  • Cite this

    Sato, I., Umemura, M., Mitsudo, K., Kioi, M., Nakashima, H., Iwai, T., Feng, X., Oda, K., Miyajima, A., Makino, A., Iwai, M., Fujita, T., Yokoyama, U., Okumura, S., Sato, M., Eguchi, H., Tohnai, I., & Ishikawa, Y. (2014). Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells. Journal of Physiological Sciences, 64(3), 177-183. https://doi.org/10.1007/s12576-014-0309-8