Hypocretin/orexin and energy expenditure

J. A. Teske, C. J. Billington, C. M. Kotz

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The hypocretins or orexins are endogenous neuropeptides synthesized in discrete lateral, perifornical and dorsal hypothalamic neurones. These multi-functional neuropeptides modulate energy homeostasis, arousal, stress, reward, reproduction and cardiovascular function. This review summarizes the role of hypocretins in modulating non-sleep-related energy expenditure with specific focus on the augmentation of whole body energy expenditure as well as hypocretin-induced physical activity and sympathetic outflow. We compare the efficacy of hypocretin-1 and 2 on energy expenditure and evaluate whether the literature implicates hypocretin signalling though the hypocretin-1 and -2 receptor as having shared and or functionally specific physiological effects. Thus far data suggest that hypocretin-1 has a more robust stimulatory effect relative to hypocretin-2. Furthermore, hypocretin-1 receptor predominantly mediates behaviours known to influence energy expenditure. Further studies on the hypocretin-2 receptor are needed.

Original languageEnglish (US)
Pages (from-to)303-312
Number of pages10
JournalActa Physiologica
Volume198
Issue number3
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

Keywords

  • Diet-induced obesity
  • Neuropeptide
  • Spontaneous physical activity

ASJC Scopus subject areas

  • Physiology

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