Hypoglycemic and analgesic activity of ethanol extract of polyalthia longifolia leaves on experimental mice

M. Khairuzzaman, A. K. Azad, Ahsan Habib, Atiqur Rahman, Jannatun Ferdous, Ariful Islam, Tauhidur Rahman, G. Tawabul Alam Chowdhury

Research output: Contribution to journalArticle

Abstract

Diabetes is emerging new threats through different complications with time. Present study was designed to evaluate a hypoglycemic activity of Polyalthia longifolia leaves ethanol extract of along with analgesic activity. Oral glucose tolerance test showed significant result at dose 500mg/kg body weight of mice but not significant at dose 250mg/kg compare to control group where metformin was used as a reference standard. Analgesic activity of Polyalthia longifolia extract by acetic acid induced writhing method also showed mentionable effects that was 58% at dose 500mg/kg and 70% at 250mg/kg compare with standard diclofenac 78% writhing inhibition.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalPharmacologyonline
Volume3
StatePublished - Dec 30 2018
Externally publishedYes

Fingerprint

Polyalthia
Hypoglycemic Agents
Analgesics
Ethanol
Diclofenac
Metformin
Glucose Tolerance Test
Acetic Acid
Body Weight
Control Groups

Keywords

  • Acetic acid
  • Analgesic activity
  • Glucose tolerance
  • Hypoglycemic
  • Polyalthia longifolia

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Khairuzzaman, M., Azad, A. K., Habib, A., Rahman, A., Ferdous, J., Islam, A., ... Chowdhury, G. T. A. (2018). Hypoglycemic and analgesic activity of ethanol extract of polyalthia longifolia leaves on experimental mice. Pharmacologyonline, 3, 229-234.

Hypoglycemic and analgesic activity of ethanol extract of polyalthia longifolia leaves on experimental mice. / Khairuzzaman, M.; Azad, A. K.; Habib, Ahsan; Rahman, Atiqur; Ferdous, Jannatun; Islam, Ariful; Rahman, Tauhidur; Chowdhury, G. Tawabul Alam.

In: Pharmacologyonline, Vol. 3, 30.12.2018, p. 229-234.

Research output: Contribution to journalArticle

Khairuzzaman, M, Azad, AK, Habib, A, Rahman, A, Ferdous, J, Islam, A, Rahman, T & Chowdhury, GTA 2018, 'Hypoglycemic and analgesic activity of ethanol extract of polyalthia longifolia leaves on experimental mice', Pharmacologyonline, vol. 3, pp. 229-234.
Khairuzzaman M, Azad AK, Habib A, Rahman A, Ferdous J, Islam A et al. Hypoglycemic and analgesic activity of ethanol extract of polyalthia longifolia leaves on experimental mice. Pharmacologyonline. 2018 Dec 30;3:229-234.
Khairuzzaman, M. ; Azad, A. K. ; Habib, Ahsan ; Rahman, Atiqur ; Ferdous, Jannatun ; Islam, Ariful ; Rahman, Tauhidur ; Chowdhury, G. Tawabul Alam. / Hypoglycemic and analgesic activity of ethanol extract of polyalthia longifolia leaves on experimental mice. In: Pharmacologyonline. 2018 ; Vol. 3. pp. 229-234.
@article{652350738e5145569ee873dcb4727c98,
title = "Hypoglycemic and analgesic activity of ethanol extract of polyalthia longifolia leaves on experimental mice",
abstract = "Diabetes is emerging new threats through different complications with time. Present study was designed to evaluate a hypoglycemic activity of Polyalthia longifolia leaves ethanol extract of along with analgesic activity. Oral glucose tolerance test showed significant result at dose 500mg/kg body weight of mice but not significant at dose 250mg/kg compare to control group where metformin was used as a reference standard. Analgesic activity of Polyalthia longifolia extract by acetic acid induced writhing method also showed mentionable effects that was 58{\%} at dose 500mg/kg and 70{\%} at 250mg/kg compare with standard diclofenac 78{\%} writhing inhibition.",
keywords = "Acetic acid, Analgesic activity, Glucose tolerance, Hypoglycemic, Polyalthia longifolia",
author = "M. Khairuzzaman and Azad, {A. K.} and Ahsan Habib and Atiqur Rahman and Jannatun Ferdous and Ariful Islam and Tauhidur Rahman and Chowdhury, {G. Tawabul Alam}",
year = "2018",
month = "12",
day = "30",
language = "English (US)",
volume = "3",
pages = "229--234",
journal = "Pharmacologyonline",
issn = "1827-8620",
publisher = "SILAE - Societa Italo-Latinoamericana di Etnomedicina",

}

TY - JOUR

T1 - Hypoglycemic and analgesic activity of ethanol extract of polyalthia longifolia leaves on experimental mice

AU - Khairuzzaman, M.

AU - Azad, A. K.

AU - Habib, Ahsan

AU - Rahman, Atiqur

AU - Ferdous, Jannatun

AU - Islam, Ariful

AU - Rahman, Tauhidur

AU - Chowdhury, G. Tawabul Alam

PY - 2018/12/30

Y1 - 2018/12/30

N2 - Diabetes is emerging new threats through different complications with time. Present study was designed to evaluate a hypoglycemic activity of Polyalthia longifolia leaves ethanol extract of along with analgesic activity. Oral glucose tolerance test showed significant result at dose 500mg/kg body weight of mice but not significant at dose 250mg/kg compare to control group where metformin was used as a reference standard. Analgesic activity of Polyalthia longifolia extract by acetic acid induced writhing method also showed mentionable effects that was 58% at dose 500mg/kg and 70% at 250mg/kg compare with standard diclofenac 78% writhing inhibition.

AB - Diabetes is emerging new threats through different complications with time. Present study was designed to evaluate a hypoglycemic activity of Polyalthia longifolia leaves ethanol extract of along with analgesic activity. Oral glucose tolerance test showed significant result at dose 500mg/kg body weight of mice but not significant at dose 250mg/kg compare to control group where metformin was used as a reference standard. Analgesic activity of Polyalthia longifolia extract by acetic acid induced writhing method also showed mentionable effects that was 58% at dose 500mg/kg and 70% at 250mg/kg compare with standard diclofenac 78% writhing inhibition.

KW - Acetic acid

KW - Analgesic activity

KW - Glucose tolerance

KW - Hypoglycemic

KW - Polyalthia longifolia

UR - http://www.scopus.com/inward/record.url?scp=85059638809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059638809&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 229

EP - 234

JO - Pharmacologyonline

JF - Pharmacologyonline

SN - 1827-8620

ER -