The regulation of ion channel activity is key to the maintenance of cellular excitability in many cell types. In vascular smooth muscle, the activity of K+ channels is essential to the control of membrane excitability in that K+ channels are responsible for setting the resting membrane potential (RMP) at relatively negative membrane potentials (1). Alteration of K+ channel activity or gene expression will therefore have a major impact on cell excitability. Indeed, dysfunctional ion channels permeable to K+, Na+, Ca2+, and Cl have been involved in many forms of cardiovascular disease (2-5).
|Original language||English (US)|
|Title of host publication||Ion Channels in the Pulmonary Vasculature|
|Number of pages||30|
|ISBN (Print)||0824759680, 9780824759681|
|State||Published - Jan 1 2005|
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