Hypoxia-induced modulation of O2-sensitive K+ channels in pulmonary vascular smooth muscle cells

Carmelle V. Remillard, Oleksandr Platoshyn, Tiffany Sison, Jason Yuan

Research output: Chapter in Book/Report/Conference proceedingChapter


The regulation of ion channel activity is key to the maintenance of cellular excitability in many cell types. In vascular smooth muscle, the activity of K+ channels is essential to the control of membrane excitability in that K+ channels are responsible for setting the resting membrane potential (RMP) at relatively negative membrane potentials (1). Alteration of K+ channel activity or gene expression will therefore have a major impact on cell excitability. Indeed, dysfunctional ion channels permeable to K+, Na+, Ca2+, and Cl have been involved in many forms of cardiovascular disease (2-5).

Original languageEnglish (US)
Title of host publicationIon Channels in the Pulmonary Vasculature
PublisherCRC Press
Number of pages30
ISBN (Electronic)9780849350375
ISBN (Print)0824759680, 9780824759681
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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