Hypoxic pulmonary vasoconstriction: Role of ion channels

Joseph R.H. Mauban, Carmelle V. Remillard, Jason X.J. Yuan

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Acute hypoxia induces pulmonary vasoconstriction and chronic hypoxia causes structural changes of the pulmonary vasculature including arterial medial hypertrophy. Electro- and pharmacomechanical mechanisms are involved in regulating pulmonary vasomotor tone, whereas intracellular Ca2+ serves as an important signal in regulating contraction and proliferation of pulmonary artery smooth muscle cells. Herein, we provide a basic overview of the cellular mechanisms involved in the development of hypoxic pulmonary vasoconstriction. Our discussion focuses on the roles of ion channels permeable to K+ and Ca2+, membrane potential, and cytoplasmic Ca2+ in the development of acute hypoxic pulmonary vasoconstriction and chronic hypoxia-mediated pulmonary vascular remodeling.

Original languageEnglish (US)
Pages (from-to)415-420
Number of pages6
JournalJournal of Applied Physiology
Issue number1
StatePublished - Jan 2005
Externally publishedYes


  • Calcium
  • Hypoxia
  • Proliferation
  • Remodeling

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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