Hypoxic pulmonary vasoconstriction: Role of voltage-gated potassium channels

Michèle Sweeney, Jason X.J. Yuan

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Activity of voltage-gated potassium (Kv) channels controls membrane potential, which subsequently regulates cytoplasmic free calcium concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs). Acute hypoxia inhibits Kv channel function in PASMCs, inducing membrane depolarization and a rise in [Ca2+]cyt that triggers vasoconstriction. Prolonged hypoxia inhibits expression of Kv channels and reduces Kv channel currents in PASMCs. The consequent membrane depolarization raises [Ca2+]cyt, thus stimulating PASMC proliferation. The present review discusses recent evidence for the involvement of Kv channels in initiation of hypoxic pulmonary vasoconstriction and in chronic hypoxia-induced pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalRespiratory Research
Volume1
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Hypoxia
  • Intracellular calcium
  • Membrane potential
  • Smooth muscle

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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