I. High performance liquid chromatography of pharmacologically active amines and peptides in biological materials

Thomas P. Davis, Hans Schoemaker, Andrew Chen, Henry I. Yamamura

Research output: Contribution to journalShort survey

19 Scopus citations

Abstract

Precise and quantitative reversed-phase high performance liquid chromatographic (HPLC) procedures are described which can be used in biogenic amine and neuropeptide research. The amine procedure was applied to various pharmacological matrices including plasma, heart tissue and brain. The use of peptide HPLC as an analytical tool for various neuropeptides is illustrated by studies on des-tyrosine-γ-endorphin (DTγE) metabolism in the brain and the stability of an ACTH (ORG-2766) analogue during a chronic infusion in rats. The power of HPLC as a research tool in peptide pharmacology is described, discussed and demonstrated as an aid in the understanding of the pharmacological effects of exogenous peptides and the function of the brain.

Original languageEnglish (US)
Pages (from-to)971-987
Number of pages17
JournalLife Sciences
Volume30
Issue number12
DOIs
StatePublished - Mar 22 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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