Ia‐bearing cells promote the concanavalin A mitogenic response of la‐negative T cells

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26 Scopus citations

Abstract

Nylon wool column‐purified T cell populations depleted of la‐bearing cells do not respond to the T cell mitogen concanavalin A (ConA). The response of this population can be restored by admixture of untreated nylon wool‐nonadherent T cells. These promoter cells express Thy‐1, are not sensitive to mitomycin C treatment and cannot be replaced with adherent spleen cells. Experiments using the T6 chromosome marker demonstrate that Ia‐depleted populations respond to ConA only in the presence of the Ia‐positive population.

Original languageEnglish (US)
Pages (from-to)447-450
Number of pages4
JournalEuropean Journal of Immunology
Volume7
Issue number7
DOIs
StatePublished - Jul 1977
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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