Nylon wool column‐purified T cell populations depleted of la‐bearing cells do not respond to the T cell mitogen concanavalin A (ConA). The response of this population can be restored by admixture of untreated nylon wool‐nonadherent T cells. These promoter cells express Thy‐1, are not sensitive to mitomycin C treatment and cannot be replaced with adherent spleen cells. Experiments using the T6 chromosome marker demonstrate that Ia‐depleted populations respond to ConA only in the presence of the Ia‐positive population.
ASJC Scopus subject areas
- Immunology and Allergy