Identification and 3-D quantification of atherosclerosis using magnetic resonance imaging

M. B. Merickel, C. S. Carman, J. R. Brookeman, J. P. Mugler, Michael F Brown, C. R. Ayers

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Cardiovascular disease due to atherosclerosis is a leading cause of death in the United States as well as other developed countries. This paper describes the development of image processing, pattern recognition, and graphical display techniques to non-invasively quantify the atherosclerotic disease process using magnetic resonance imaging (MRI). We have demonstrated the ability to identify the soft tissue classes of (1) normal, smooth muscle wall, (2) fatty plaque, (3) complex, fibrous plaque, and (4) calcified plaque. The objective of this work has been to combine functional information, such as plaque tissue type, with structural information, represented by 3-D display of vessel structure, into a single composite display. The results of this work provide a "high information content" display which will aid in the diagnosis and analysis of the atherosclerotic disease process, and permit detailed and quantitative studies to assess the effectiveness of therapies (e.g. changes in diet, exercise and drug administration).

Original languageEnglish (US)
Pages (from-to)89-102
Number of pages14
JournalComputers in Biology and Medicine
Volume18
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Magnetic resonance
Atherosclerosis
Display devices
Magnetic Resonance Imaging
Data Display
Imaging techniques
Aptitude
Developed Countries
Smooth Muscle
Cause of Death
Cardiovascular Diseases
Tissue
Diet
Nutrition
Pharmaceutical Preparations
Pattern recognition
Muscle
Image processing
Composite materials
Therapeutics

Keywords

  • 3-D display
  • Atherosclerosis
  • Image analysis
  • magnetic resonance imaging
  • Pattern recognition

ASJC Scopus subject areas

  • Computer Science Applications

Cite this

Identification and 3-D quantification of atherosclerosis using magnetic resonance imaging. / Merickel, M. B.; Carman, C. S.; Brookeman, J. R.; Mugler, J. P.; Brown, Michael F; Ayers, C. R.

In: Computers in Biology and Medicine, Vol. 18, No. 2, 1988, p. 89-102.

Research output: Contribution to journalArticle

Merickel, M. B. ; Carman, C. S. ; Brookeman, J. R. ; Mugler, J. P. ; Brown, Michael F ; Ayers, C. R. / Identification and 3-D quantification of atherosclerosis using magnetic resonance imaging. In: Computers in Biology and Medicine. 1988 ; Vol. 18, No. 2. pp. 89-102.
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