Identification and treatment of nontuberculous Mycobacterium sinusitis

Jeffrey D. Suh, Vijay R. Ramakrishnan, Bobby Tajudeen, Christine Reger, David W. Kennedy, Alexander G Chiu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The purpose of this study was to identify the incidence of atypical Mycobacterium identified by routine sinus cultures and review the recent literature on management. Methods: A retrospective case series was performed in a tertiary academic hospital. A retrospective case series of all patients treated with atypical Mycobacterium rhinosinusitis from 2005 to 2010 was performed. Cases were identified from a prospective database of 676 endoscopically guided sinus cultures. Results: Eight patients with atypical Mycobacterium sinusitis were identified. There were five women and three men. Median age was 63 years (range, 55-71 years). All patients had prior endoscopic sinus surgery a median of 14 months (range, 0.8-162 months) before a positive culture result. Species identified included Mycobacterium chelonae, Mycobacterium fortuitum, Mycobacterium abscessus, and Mycobacterium avium complex. Chief presenting symptoms were postnasal discharge (88%), followed by decreased smell and taste (63%), and facial pain/pressure (38%). Patients were treated based on sensitivity results with long-term oral antibiotics for at least 2 months based on improvements on endoscopy. Median follow-up for patients in this study after treatment was 1.3 years (range, 0.6-4.6 years). Conclusion: In this study, atypical mycobacteria were identified in <1% of sinus cultures. Prolonged, culture-directed antibiotic therapy remains the mainstay of treatment when there is clinical evidence of infection. Previous endoscopic sinus surgery may represent a risk factor for colonization and subsequent infection. Further research is necessary to determine the optimal treatment duration and management to prevent disease relapse.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalAmerican Journal of Rhinology and Allergy
Volume25
Issue number6
DOIs
StatePublished - Nov 2011

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Nontuberculous Mycobacteria
Sinusitis
Mycobacterium chelonae
Mycobacterium fortuitum
Anti-Bacterial Agents
Therapeutics
Mycobacterium avium Complex
Facial Pain
Smell
Mycobacterium
Infection
Tertiary Care Centers
Endoscopy
Databases
Pressure
Recurrence
Incidence
Research

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Immunology and Allergy

Cite this

Identification and treatment of nontuberculous Mycobacterium sinusitis. / Suh, Jeffrey D.; Ramakrishnan, Vijay R.; Tajudeen, Bobby; Reger, Christine; Kennedy, David W.; Chiu, Alexander G.

In: American Journal of Rhinology and Allergy, Vol. 25, No. 6, 11.2011, p. 421-424.

Research output: Contribution to journalArticle

Suh, Jeffrey D. ; Ramakrishnan, Vijay R. ; Tajudeen, Bobby ; Reger, Christine ; Kennedy, David W. ; Chiu, Alexander G. / Identification and treatment of nontuberculous Mycobacterium sinusitis. In: American Journal of Rhinology and Allergy. 2011 ; Vol. 25, No. 6. pp. 421-424.
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