Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

Carika Weldon, Isabelle Behm-Ansmant, Laurence H. Hurley, Glenn A. Burley, Christiane Branlant, Ian C. Eperon, Cyril Dominguez

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.

Original languageEnglish (US)
Pages (from-to)18-20
Number of pages3
JournalNature chemical biology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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