Image overlay solution based on threshold detection for a compact near infrared fluorescence goggle system

Shengkui Gao, Suman B. Mondal, Nan Zhu, Rongguang Liang, Samuel Achilefu, Viktor Gruev

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Near infrared (NIR) fluorescence imaging has shown great potential for various clinical procedures, including intraoperative image guidance. However, existing NIR fluorescence imaging systems either have a large footprint or are handheld, which limits their usage in intraoperative applications. We present a compact NIR fluorescence imaging system (NFIS) with an image overlay solution based on threshold detection, which can be easily integrated with a goggle display system for intraoperative guidance. The proposed NFIS achieves compactness, light weight, hands-free operation, high-precision superimposition, and a real-time frame rate. In addition, the miniature and ultra-lightweight light-emitting diode tracking pod is easy to incorporate with NIR fluorescence imaging. Based on experimental evaluation, the proposed NFIS solution has a lower detection limit of 25 nM of indocyanine green at 27 fps and realizes a highly precise image overlay of NIR and visible images of mice in vivo. The overlay error is limited within a 2-mm scale at a 65-cm working distance, which is highly reliable for clinical study and surgical use.

Original languageEnglish (US)
Article number016018
JournalJournal of Biomedical Optics
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

goggles
Goggles
Fluorescence
Infrared radiation
Imaging systems
fluorescence
thresholds
Imaging techniques
Indocyanine Green
void ratio
footprints
display devices
Light emitting diodes
mice
light emitting diodes
Display devices
evaluation

Keywords

  • complementary metal-oxide semiconductor imaging sensor
  • head-mounted display goggle
  • image guided surgery
  • image overlay
  • near infrared fluorescence
  • threshold detection

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Image overlay solution based on threshold detection for a compact near infrared fluorescence goggle system. / Gao, Shengkui; Mondal, Suman B.; Zhu, Nan; Liang, Rongguang; Achilefu, Samuel; Gruev, Viktor.

In: Journal of Biomedical Optics, Vol. 20, No. 1, 016018, 01.01.2015.

Research output: Contribution to journalArticle

Gao, Shengkui ; Mondal, Suman B. ; Zhu, Nan ; Liang, Rongguang ; Achilefu, Samuel ; Gruev, Viktor. / Image overlay solution based on threshold detection for a compact near infrared fluorescence goggle system. In: Journal of Biomedical Optics. 2015 ; Vol. 20, No. 1.
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