Imaging of in vitro parenteral drug precipitation

Daniel C. Evans, Michael W. Kudenov, Kimberly C. Sassenrath, Eustace L. Dereniak, Samuel H Yalkowsky

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Solid particulate matter introduced into the bloodstream as a result of parenteral drug administration can produce serious pathological conditions. Particulate matter that cannot be eliminated by pre-infusion filtration is often the result of drug precipitation that occurs when certain parenteral formulations are mixed with blood. A new device is designed to model the mixing of drug formulations with flowing blood utilizing a uniquely designed flow cell and a CCD camera to view the formulation as it is mixed with a blood surrogate in real time. The performance of the proposed device is measured using 3 commercially available parenteral formulations previously tested using a validated in vitro model.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume512
Issue number1
DOIs
StatePublished - Oct 15 2016

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ASJC Scopus subject areas

  • Pharmaceutical Science

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