Imaging of systemic mastocytosis by FDG-PET/CT demonstrates increased activity in cortical bone

Roger T. Tomihama, James C. McEachen, Phillip H Kuo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A patient with systemic mastocytosis underwent a FDG-PET/CT scan. CT demonstrated loss of corticomedullary differentiation in the axial skeleton and thickening of cortical bone in the appendicular skeleton consistent with myelofibrosis and osteosclerosis. Remarkably, the bones of the lower extremities displayed increased uptake of FDG in the cortical bone and marrow space. A diffuse pattern of uptake was also seen in the bones of the axial skeleton instead of the typical pattern of FDG uptake confined to the marrow consistent with the loss of corticomedullary differentiation. We hypothesize that the increased FDG uptake in cortical bone is due to increased osteoblastic activity causing the myelofibrosis.

Original languageEnglish (US)
Pages (from-to)220-223
Number of pages4
JournalClinical Nuclear Medicine
Volume33
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Systemic Mastocytosis
Skeleton
Primary Myelofibrosis
Bones of Lower Extremity
Bone Marrow
Osteosclerosis
Bone and Bones
Cortical Bone

Keywords

  • Fluorodeoxyglucose
  • Mastocytosis
  • Myelofibrosis
  • PET
  • PET/CT
  • Skeleton

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Imaging of systemic mastocytosis by FDG-PET/CT demonstrates increased activity in cortical bone. / Tomihama, Roger T.; McEachen, James C.; Kuo, Phillip H.

In: Clinical Nuclear Medicine, Vol. 33, No. 3, 03.2008, p. 220-223.

Research output: Contribution to journalArticle

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