Imaging of the ovary

Molly A. Brewer, Urs Utzinger, Jennifer K Barton, James B. Hoying, Nathaniel D. Kirkpatrick, William R. Brands, John R. Davis, Katherine Hunt, Sally J Stevens, Arthur F Gmitro

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Epithelial ovarian cancer has the highest mortality rate among the gynecologic cancers and spreads beyond the ovary in 90% of the women diagnosed with ovarian cancer. Detection before the disease has spread beyond the ovary would significantly improve the survival from ovarian cancer, which is currently only 30% over 5 years, despite extensive efforts to improve the survival. This study describes initial investigation of the use of optical technologies to improve the outcome for this disease by detecting cancers at an earlier and more treatable stage. Women undergoing oophorectomy were recruited for this study. Ovaries were harvested for fluorescence spectroscopy, confocal microscopy, and optical coherence tomography. Fluorescence spectroscopy showed large diagnostic differences between normal and abnormal tissue at 270 and 340 nm excitation. Optical coherence tomography was able to image up to 2mm deep into the ovary with particular patterns of backscattered intensity observed in normal versus abnormal tissue. Fluorescence confocal microscopy was able to visualize sub-cellular structures of the surface epithelium and underlying cell layers. Optical imaging and/or spectroscopy has the potential to improve the diagnostic capability in the ovary, but extended systematic investigations are needed to identify the unique signatures of disease. The combination of optical technologies supported by modern molecular biology may lead to an instrument that can accurately detect early carcinogenesis.

Original languageEnglish (US)
Pages (from-to)617-627
Number of pages11
JournalTechnology in Cancer Research and Treatment
Volume3
Issue number6
StatePublished - Dec 2004

Fingerprint

Ovary
Fluorescence Spectrometry
Optical Coherence Tomography
Confocal Microscopy
Ovarian Neoplasms
Technology
Survival
Optical Imaging
Ovariectomy
Cellular Structures
Fluorescence Microscopy
Molecular Biology
Neoplasms
Spectrum Analysis
Carcinogenesis
Epithelium
Mortality

Keywords

  • Ovarian cancer imaging

ASJC Scopus subject areas

  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Brewer, M. A., Utzinger, U., Barton, J. K., Hoying, J. B., Kirkpatrick, N. D., Brands, W. R., ... Gmitro, A. F. (2004). Imaging of the ovary. Technology in Cancer Research and Treatment, 3(6), 617-627.

Imaging of the ovary. / Brewer, Molly A.; Utzinger, Urs; Barton, Jennifer K; Hoying, James B.; Kirkpatrick, Nathaniel D.; Brands, William R.; Davis, John R.; Hunt, Katherine; Stevens, Sally J; Gmitro, Arthur F.

In: Technology in Cancer Research and Treatment, Vol. 3, No. 6, 12.2004, p. 617-627.

Research output: Contribution to journalArticle

Brewer, MA, Utzinger, U, Barton, JK, Hoying, JB, Kirkpatrick, ND, Brands, WR, Davis, JR, Hunt, K, Stevens, SJ & Gmitro, AF 2004, 'Imaging of the ovary', Technology in Cancer Research and Treatment, vol. 3, no. 6, pp. 617-627.
Brewer MA, Utzinger U, Barton JK, Hoying JB, Kirkpatrick ND, Brands WR et al. Imaging of the ovary. Technology in Cancer Research and Treatment. 2004 Dec;3(6):617-627.
Brewer, Molly A. ; Utzinger, Urs ; Barton, Jennifer K ; Hoying, James B. ; Kirkpatrick, Nathaniel D. ; Brands, William R. ; Davis, John R. ; Hunt, Katherine ; Stevens, Sally J ; Gmitro, Arthur F. / Imaging of the ovary. In: Technology in Cancer Research and Treatment. 2004 ; Vol. 3, No. 6. pp. 617-627.
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