Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system

Zhonglin Liu, Gail D. Stevenson, Harrison H. Barrett, George A. Kastis, Michael Bettan, Lars R. Furenlid, Donald W. Wilson, James M. Woolfenden

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sensitive MCF7/S tumors. Furifosmin exhibited greater washout from both MCF7/S and MCF7/D40 than sestamibi, while tetrofosmin washout was greater than sestamibi in MCF7/D40 only. Feasibility of the monocationic agents for characterizing MDR expression was well clarified with FASTSPECT imaging.

Original languageEnglish (US)
Pages (from-to)53-65
Number of pages13
JournalNuclear Medicine and Biology
Volume31
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Breast tumor
  • High-resolution SPECT
  • Multidrug resistance
  • Tc- sestamibi
  • Tc-furifosmin
  • Tc-tetrofosmin

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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