Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system

Zhonglin Liu, Gail D. Stevenson, Harrison H Barrett, George A. Kastis, Michael Bettan, Lars R Furenlid, Donald W. Wilson, James M. Woolfenden

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sensitive MCF7/S tumors. Furifosmin exhibited greater washout from both MCF7/S and MCF7/D40 than sestamibi, while tetrofosmin washout was greater than sestamibi in MCF7/D40 only. Feasibility of the monocationic agents for characterizing MDR expression was well clarified with FASTSPECT imaging.

Original languageEnglish (US)
Pages (from-to)53-65
Number of pages13
JournalNuclear Medicine and Biology
Volume31
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Multiple Drug Resistance
Single-Photon Emission-Computed Tomography
Breast Neoplasms
Technetium Tc 99m Sestamibi
Pharmaceutical Preparations
Neoplasms

Keywords

  • Tc- sestamibi
  • Tc-furifosmin
  • Tc-tetrofosmin
  • Breast tumor
  • High-resolution SPECT
  • Multidrug resistance

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system. / Liu, Zhonglin; Stevenson, Gail D.; Barrett, Harrison H; Kastis, George A.; Bettan, Michael; Furenlid, Lars R; Wilson, Donald W.; Woolfenden, James M.

In: Nuclear Medicine and Biology, Vol. 31, No. 1, 01.2004, p. 53-65.

Research output: Contribution to journalArticle

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