Immediate-early gene induction in hippocampus and cortex as a result of novel experience is not directly related to the stressfulness of that experience

Thaddeus Wesley Warren Pace, Reginald Gaylord, Farran Topczewski, Milena Girotti, Benjamin Rubin, Robert L. Spencer

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The stressful quality of an experience, as perceived by rats, is believed to be largely represented by the magnitude of a hypothalamic-pituitary-adrenal (HPA) axis response. The hippocampus may be especially important for assessing the stressfulness of psychological stressors such as novel experience. If such is the case then experience-dependent immediate-early gene expression levels within the hippocampus may parallel relative levels of HPA axis activity. We examined this prospect in rats that were placed in four different novel environments (empty housing tub, circular arena, elevated pedestal or restraint tube). Restraint and pedestal produced the largest magnitude of increased ACTH and corticosterone secretion, arena an intermediate level (Experiment 2) and tub the least magnitude of increase. We saw a very similar experience-dependent pattern of relative Fos protein, c-fos mRNA and zif268 mRNA expression in the paraventricular nucleus of the hypothalamus. However, in hippocampus (and select regions of cortex), immediate-early gene expression was associated with the exploratory potential of the novel experience rather than level of HPA axis activity; pedestal and arena elicited the greatest immediate-early gene expression, tub an intermediate level and restraint the least amount of expression. We conclude that the stressfulness of psychological stressors is not represented by the amount of immediate-early gene induction elicited in hippocampus and cortex, nor does there appear to be a general enhancing or depressive influence of acute stress on immediate-early gene induction in those brain regions.

Original languageEnglish (US)
Pages (from-to)1679-1690
Number of pages12
JournalEuropean Journal of Neuroscience
Volume22
Issue number7
DOIs
StatePublished - Oct 2005
Externally publishedYes

Fingerprint

Immediate-Early Genes
Hippocampus
Proto-Oncogene Proteins c-fos
Gene Expression
Psychology
Messenger RNA
Paraventricular Hypothalamic Nucleus
Corticosterone
Adrenocorticotropic Hormone
Hypothalamus
Brain

Keywords

  • Acth
  • c-fos
  • Corticosterone
  • Rat
  • Stress
  • zif268

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Immediate-early gene induction in hippocampus and cortex as a result of novel experience is not directly related to the stressfulness of that experience. / Pace, Thaddeus Wesley Warren; Gaylord, Reginald; Topczewski, Farran; Girotti, Milena; Rubin, Benjamin; Spencer, Robert L.

In: European Journal of Neuroscience, Vol. 22, No. 7, 10.2005, p. 1679-1690.

Research output: Contribution to journalArticle

Pace, Thaddeus Wesley Warren ; Gaylord, Reginald ; Topczewski, Farran ; Girotti, Milena ; Rubin, Benjamin ; Spencer, Robert L. / Immediate-early gene induction in hippocampus and cortex as a result of novel experience is not directly related to the stressfulness of that experience. In: European Journal of Neuroscience. 2005 ; Vol. 22, No. 7. pp. 1679-1690.
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