Immune control of coxsackievirus-induced cardiopathology.

R. T. Sepúlveda, Ronald R Watson

Research output: Contribution to journalArticle

Abstract

Retrovirally induced acquired immunodeficiency in humans and mice induces immune dysregulation as well as increased oxidative stress as the disease progresses. Both immunodeficiency and oxidative stress make the host susceptible to the development of heat disease either by physiological changes or by the direct influence of cardiovirulance. Antioxidant supplementation has been shown to influence the onset as well as the degree of cardiopathology due to primary infections or co-infections. An alternative treatment is the use of peptide immunomodulatory therapy to enhance cytokine production, immune cell function and resistance to opportunistic infections. This review compiles our in vivo and in vitro studies on the effects of antioxidant supplementation and peptide therapy on the immune control of coxsackievirus induced cardiopathology in AIDS.

Original languageEnglish (US)
Pages (from-to)171-180
Number of pages10
JournalCellular and molecular biology (Noisy-le-Grand, France)
Volume49
Issue number2
StatePublished - Mar 2003
Externally publishedYes

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Oxidative stress
Enterovirus
Oxidative Stress
Antioxidants
Peptides
Immunomodulation
Opportunistic Infections
Coinfection
Acquired Immunodeficiency Syndrome
Hot Temperature
Cytokines
Therapeutics
Infection
In Vitro Techniques

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Immune control of coxsackievirus-induced cardiopathology. / Sepúlveda, R. T.; Watson, Ronald R.

In: Cellular and molecular biology (Noisy-le-Grand, France), Vol. 49, No. 2, 03.2003, p. 171-180.

Research output: Contribution to journalArticle

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