Immune mechanisms in leukemia. Role of the Ia antigens

O. A. Lukasewycz, Jeffrey A Frelinger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have shown that the selective removal of cells possessing Ia determinants coded by the I-A, I-B, and I-J regions of the H-2 gene complex completely abrogates the protective capacity of nylon-wool-purified T lymphocytes against leukemic challenge. This suggests that the Ia antigen bearing T cells play an important role in tumor immunity.

Original languageEnglish (US)
Pages (from-to)1077-1081
Number of pages5
JournalJournal of Experimental Medicine
Volume145
Issue number4
StatePublished - 1977
Externally publishedYes

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Histocompatibility Antigens Class II
Leukemia
T-Lymphocytes
Wool
Nylons
Immunity
Genes
Neoplasms

ASJC Scopus subject areas

  • Immunology

Cite this

Immune mechanisms in leukemia. Role of the Ia antigens. / Lukasewycz, O. A.; Frelinger, Jeffrey A.

In: Journal of Experimental Medicine, Vol. 145, No. 4, 1977, p. 1077-1081.

Research output: Contribution to journalArticle

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