Immune mechanisms in leukemia: Role of the ia antigens*

Omelan A. Lukasewycz, Jeffrey A. Frelinger

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We have shown that the selective removal of cells possessing Ia determinants coded by the I-A, I-B, and I-J regions of the H-2 gene complex completely abrogates the protective capacity of nylon-wool-purified T lymphocytes against leukemic challenge. This suggests that the Ia antigen bearing T cells play an important role in tumor immunity.

Original languageEnglish (US)
Pages (from-to)1077-1081
Number of pages5
JournalJournal of Experimental Medicine
Volume145
Issue number4
DOIs
StatePublished - Apr 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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