Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature

VRC Production Program

Research output: Contribution to journalArticle

Abstract

Immune monitoring of B cells in response to vaccination can enable early insights, even in the absence of serum neutralization. Cheng et al. observe an early B cell signature in NHPs predictive of the vaccine outcome, with priming of HIV FP imprinting cross-clade neutralizing FP-directed vaccine responses.

Original languageEnglish (US)
Article number107981
JournalCell Reports
Volume32
Issue number5
DOIs
StatePublished - Aug 4 2020

Keywords

  • early signature
  • envelope trimer
  • fusion peptide
  • HIV vaccine
  • immune monitoring
  • immunization regimen
  • immunogen cocktail
  • imprinting
  • NHP
  • prime-boost immunization

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature'. Together they form a unique fingerprint.

  • Cite this