Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections

Thomas F. Marandu, Jennifer D. Oduro, Lisa Borkner, Iryna Dekhtiarenko, Jennifer L. Uhrlaub, Anja Drabig, Andrea Kröger, Janko Nikolich-Zugich, Luka Cicin-Sain

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.

Original languageEnglish (US)
Pages (from-to)11715-11717
Number of pages3
JournalJournal of virology
Volume89
Issue number22
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Marandu, T. F., Oduro, J. D., Borkner, L., Dekhtiarenko, I., Uhrlaub, J. L., Drabig, A., Kröger, A., Nikolich-Zugich, J., & Cicin-Sain, L. (2015). Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections. Journal of virology, 89(22), 11715-11717. https://doi.org/10.1128/JVI.01989-15