Immune responses in the skin in old age

Milica Vukmanovic-Stejic, Malcolm H.A. Rustin, Janko Nikolich-Zugich, Arne N. Akbar

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.

Original languageEnglish (US)
Pages (from-to)525-531
Number of pages7
JournalCurrent Opinion in Immunology
Volume23
Issue number4
DOIs
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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