Immune status of patients with multiple sclerosis: Analysis of primary and established immune responses in 24 patients

Larry E. Davis, Evan M. Hersh, John E. Curtis, Robert E. Lynch, Dewey K. Ziegler, James W. Neumann, Tom D Y Chin

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Twenty-four patients with multiple sclerosis participating in a controlled, double-blind trial of 6-mercaptopurine (6-MP) and methotrexate (MTX) were evaluated for their immunocompetence and immune responsiveness, No significant differences between the drug group and the placebo group were found in any of the tests. All patients had delayed hypersensitivity to at least one of five established delayed hypersensitivity antigens, had normal in vitro lymphocyte responses to the nonspecific mitogen phytohemagglutinin M (PHA) and to the specific mitogenic antigens streptolysin 0 and stre ptokinase-stre ptodornase, and had normal levels and prevalence of antibody to mumps, rubeola, herpes simplex, and cytomegalovirus. However, 52% of 23 patients failed to develop delayed hypersensitivity responses to the antigen keyhole limpet hemocyanin (KLH) compared with 18% of 11 normal adults. The antibody response to KLH was delayed in the patientscompared with normal adults. Antibody responses to influenza vaccination were also diminished. The defect in the immune response correlated directly with the seventy of the multiple sclerosis. If an immune defect exists in multiple sclerosis, it may be in the initiation of specific immune responses.

Original languageEnglish (US)
Pages (from-to)989
Number of pages1
JournalNeurology
Volume22
Issue number9
StatePublished - 1972
Externally publishedYes

Fingerprint

Delayed Hypersensitivity
Multiple Sclerosis
Antigens
Antibody Formation
Streptolysins
Immunocompetence
6-Mercaptopurine
Mumps
Herpes Simplex
Measles
Cytomegalovirus
Mitogens
Methotrexate
Human Influenza
Vaccination
Placebos
Lymphocytes
Antibodies
Pharmaceutical Preparations
keyhole-limpet hemocyanin

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Davis, L. E., Hersh, E. M., Curtis, J. E., Lynch, R. E., Ziegler, D. K., Neumann, J. W., & Chin, T. D. Y. (1972). Immune status of patients with multiple sclerosis: Analysis of primary and established immune responses in 24 patients. Neurology, 22(9), 989.

Immune status of patients with multiple sclerosis : Analysis of primary and established immune responses in 24 patients. / Davis, Larry E.; Hersh, Evan M.; Curtis, John E.; Lynch, Robert E.; Ziegler, Dewey K.; Neumann, James W.; Chin, Tom D Y.

In: Neurology, Vol. 22, No. 9, 1972, p. 989.

Research output: Contribution to journalArticle

Davis, LE, Hersh, EM, Curtis, JE, Lynch, RE, Ziegler, DK, Neumann, JW & Chin, TDY 1972, 'Immune status of patients with multiple sclerosis: Analysis of primary and established immune responses in 24 patients', Neurology, vol. 22, no. 9, pp. 989.
Davis, Larry E. ; Hersh, Evan M. ; Curtis, John E. ; Lynch, Robert E. ; Ziegler, Dewey K. ; Neumann, James W. ; Chin, Tom D Y. / Immune status of patients with multiple sclerosis : Analysis of primary and established immune responses in 24 patients. In: Neurology. 1972 ; Vol. 22, No. 9. pp. 989.
@article{390754c4d8dc45fbbfeab235b470cc11,
title = "Immune status of patients with multiple sclerosis: Analysis of primary and established immune responses in 24 patients",
abstract = "Twenty-four patients with multiple sclerosis participating in a controlled, double-blind trial of 6-mercaptopurine (6-MP) and methotrexate (MTX) were evaluated for their immunocompetence and immune responsiveness, No significant differences between the drug group and the placebo group were found in any of the tests. All patients had delayed hypersensitivity to at least one of five established delayed hypersensitivity antigens, had normal in vitro lymphocyte responses to the nonspecific mitogen phytohemagglutinin M (PHA) and to the specific mitogenic antigens streptolysin 0 and stre ptokinase-stre ptodornase, and had normal levels and prevalence of antibody to mumps, rubeola, herpes simplex, and cytomegalovirus. However, 52{\%} of 23 patients failed to develop delayed hypersensitivity responses to the antigen keyhole limpet hemocyanin (KLH) compared with 18{\%} of 11 normal adults. The antibody response to KLH was delayed in the patientscompared with normal adults. Antibody responses to influenza vaccination were also diminished. The defect in the immune response correlated directly with the seventy of the multiple sclerosis. If an immune defect exists in multiple sclerosis, it may be in the initiation of specific immune responses.",
author = "Davis, {Larry E.} and Hersh, {Evan M.} and Curtis, {John E.} and Lynch, {Robert E.} and Ziegler, {Dewey K.} and Neumann, {James W.} and Chin, {Tom D Y}",
year = "1972",
language = "English (US)",
volume = "22",
pages = "989",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Immune status of patients with multiple sclerosis

T2 - Analysis of primary and established immune responses in 24 patients

AU - Davis, Larry E.

AU - Hersh, Evan M.

AU - Curtis, John E.

AU - Lynch, Robert E.

AU - Ziegler, Dewey K.

AU - Neumann, James W.

AU - Chin, Tom D Y

PY - 1972

Y1 - 1972

N2 - Twenty-four patients with multiple sclerosis participating in a controlled, double-blind trial of 6-mercaptopurine (6-MP) and methotrexate (MTX) were evaluated for their immunocompetence and immune responsiveness, No significant differences between the drug group and the placebo group were found in any of the tests. All patients had delayed hypersensitivity to at least one of five established delayed hypersensitivity antigens, had normal in vitro lymphocyte responses to the nonspecific mitogen phytohemagglutinin M (PHA) and to the specific mitogenic antigens streptolysin 0 and stre ptokinase-stre ptodornase, and had normal levels and prevalence of antibody to mumps, rubeola, herpes simplex, and cytomegalovirus. However, 52% of 23 patients failed to develop delayed hypersensitivity responses to the antigen keyhole limpet hemocyanin (KLH) compared with 18% of 11 normal adults. The antibody response to KLH was delayed in the patientscompared with normal adults. Antibody responses to influenza vaccination were also diminished. The defect in the immune response correlated directly with the seventy of the multiple sclerosis. If an immune defect exists in multiple sclerosis, it may be in the initiation of specific immune responses.

AB - Twenty-four patients with multiple sclerosis participating in a controlled, double-blind trial of 6-mercaptopurine (6-MP) and methotrexate (MTX) were evaluated for their immunocompetence and immune responsiveness, No significant differences between the drug group and the placebo group were found in any of the tests. All patients had delayed hypersensitivity to at least one of five established delayed hypersensitivity antigens, had normal in vitro lymphocyte responses to the nonspecific mitogen phytohemagglutinin M (PHA) and to the specific mitogenic antigens streptolysin 0 and stre ptokinase-stre ptodornase, and had normal levels and prevalence of antibody to mumps, rubeola, herpes simplex, and cytomegalovirus. However, 52% of 23 patients failed to develop delayed hypersensitivity responses to the antigen keyhole limpet hemocyanin (KLH) compared with 18% of 11 normal adults. The antibody response to KLH was delayed in the patientscompared with normal adults. Antibody responses to influenza vaccination were also diminished. The defect in the immune response correlated directly with the seventy of the multiple sclerosis. If an immune defect exists in multiple sclerosis, it may be in the initiation of specific immune responses.

UR - http://www.scopus.com/inward/record.url?scp=84939313933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939313933&partnerID=8YFLogxK

M3 - Article

C2 - 4563026

VL - 22

SP - 989

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 9

ER -