Immunochemical characterization of the Ly-8.2 murine lymphocyte alloantigen: Possible relationship to actin

T. L. Delovitch, A. Fegelman, B. H. Barber, J. A. Frelinger

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

An immunochemical analysis of the Ly-8.2 antigen was performed. Reactivity of B10-radiolabeled T and B cell lysates with a C3H anti-AKR serum immunoprecipitates a major 43,000 m.w. protein detectable by one-dimensional gel electrophoresis. This protein can be radioiodinated, however, it does not appear to bind to lentil lectin. Two-dimensional gel electrophoresis and peptide-mapping studies indicate that this protein is structurally very similar to lymphocyte actin. The possible molecular relationship between Ly-8.2, other lymphocyte membrane antigens, and actin is discussed.

Original languageEnglish (US)
Pages (from-to)326-333
Number of pages8
JournalJournal of Immunology
Volume122
Issue number1
StatePublished - Jan 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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