Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas

Phillip H. Smith, Frederick W. Merchant, David G. Johnson, Wilfred Y. Fujimoto, Robert H. Williams

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

In rat pancreatic islets, the glucagon‐producing A‐cells also contain a GIP‐like material as revealed by the peroxidaseantiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross‐reactivity of anti‐GIP with glucagon. It is concluded either that the A‐cells synthesize a GIP‐like peptide or that it is taken up from the circulation.

Original languageEnglish (US)
Pages (from-to)585-590
Number of pages6
JournalAmerican Journal of Anatomy
Volume149
Issue number4
DOIs
StatePublished - Aug 1977
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy

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