Immunodiagnosis of acute leukemia: Detection of residual disease

J. U. Gutterman, G. Mavligit, M. A. Burgess, K. B. McCredie, C. Hunter, E. J. Freireich, Evan M Hersh

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Bone marrow cells from 25 adult patients with acute leukemia in complete remission were used to stimulate blastogenesis among autologous peripheral blood lymphocytes to detect residual leukemia among the marrow cells. Of 17 patients in remission whose peripheral blood lymphocytes failed to react to autologous remission bone marrow cells, 15 remained in complete remission (median = 10.5 months). In contrast, 5 of 8 patients in remission whose peripheral blood lymphocytes were stimulated by the bone marrow cells subsequently relapsed (median = 6.5 months). The difference in the relapse rate between the 2 groups was statistically significant (P = 0.05). The use of this immunologic technique to detect minimal residual disease in apparently remission bone marrows should improve the treatment strategy for patients with acute leukemia.

Original languageEnglish (US)
Pages (from-to)389-392
Number of pages4
JournalJournal of the National Cancer Institute
Volume53
Issue number2
StatePublished - 1974
Externally publishedYes

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Immunologic Tests
Leukemia
Bone Marrow Cells
Lymphocytes
Bone Marrow
Immunologic Techniques
Residual Neoplasm
Lymphocyte Activation
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Gutterman, J. U., Mavligit, G., Burgess, M. A., McCredie, K. B., Hunter, C., Freireich, E. J., & Hersh, E. M. (1974). Immunodiagnosis of acute leukemia: Detection of residual disease. Journal of the National Cancer Institute, 53(2), 389-392.

Immunodiagnosis of acute leukemia : Detection of residual disease. / Gutterman, J. U.; Mavligit, G.; Burgess, M. A.; McCredie, K. B.; Hunter, C.; Freireich, E. J.; Hersh, Evan M.

In: Journal of the National Cancer Institute, Vol. 53, No. 2, 1974, p. 389-392.

Research output: Contribution to journalArticle

Gutterman, JU, Mavligit, G, Burgess, MA, McCredie, KB, Hunter, C, Freireich, EJ & Hersh, EM 1974, 'Immunodiagnosis of acute leukemia: Detection of residual disease', Journal of the National Cancer Institute, vol. 53, no. 2, pp. 389-392.
Gutterman JU, Mavligit G, Burgess MA, McCredie KB, Hunter C, Freireich EJ et al. Immunodiagnosis of acute leukemia: Detection of residual disease. Journal of the National Cancer Institute. 1974;53(2):389-392.
Gutterman, J. U. ; Mavligit, G. ; Burgess, M. A. ; McCredie, K. B. ; Hunter, C. ; Freireich, E. J. ; Hersh, Evan M. / Immunodiagnosis of acute leukemia : Detection of residual disease. In: Journal of the National Cancer Institute. 1974 ; Vol. 53, No. 2. pp. 389-392.
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