Immunoglobulin E anaphylaxis in rabbits: Mechanisms of pulmonary resistance and compliance changes

Michael P Habib, A. M. Dunn, Richard E Sobonya, C. C. Baumgartener, J. D. Newell, M. Halonen

Research output: Contribution to journalArticle

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Abstract

Factors causing changes in pulmonary resistance and dynamic compliance with immunoglobulin (Ig) E anaphylaxis in spontaneously breathing rabbits were assessed in ventilated rabbits using tantalum bronchography and wet-to-dry wt ratios. Ventilated rabbits demonstrated changes in resistance and compliance similar to spontaneously breathing rabbits. Chlorpheniramine pretreatment prevented increases in resistance but not decreases in compliance. Anaphylaxis constricted small (< 1 mm) airways 20.9 ± 16.0% (mean ± SD) and intermediate between 1 and 3 mm) airways 21.8 ± 19.8%. Chlorpheniramine (10 mg/kg) prevented small airway changes and attenuated those in intermediate airways. Chlorpheniramine prevented histamine-induced constriction of small (23.6 ± 15.7%) and intermediate (17.6 ± 15.0%) airways. Lung wet-to-dry wt ratios were unchanged. Changes in resistance and compliance during rabbit IgE anaphylaxis are not due to changes in tidal volume or frequency. Histamine, via H1 receptors, is the principal mediator of pulmonary resistance increases but not dynamic compliance reductions. Chlorpheniramine-sensitive increases in resistance are caused by constrictions of intermediate and small airways, whereas the chlorpheniramine-resistant decrease in compliance is not caused directly by constriction of the smallest measurable airways (0.25 mm) or changes in lung water.

Original languageEnglish (US)
Pages (from-to)1009-1016
Number of pages8
JournalJournal of Applied Physiology
Volume64
Issue number3
StatePublished - 1988

Fingerprint

Chlorpheniramine
Lung Compliance
Anaphylaxis
Immunoglobulin E
Compliance
Rabbits
Constriction
Lung
Respiration
Bronchography
Tantalum
Histamine H1 Receptors
Tidal Volume
Pulmonary Edema
Histamine
Water

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Immunoglobulin E anaphylaxis in rabbits : Mechanisms of pulmonary resistance and compliance changes. / Habib, Michael P; Dunn, A. M.; Sobonya, Richard E; Baumgartener, C. C.; Newell, J. D.; Halonen, M.

In: Journal of Applied Physiology, Vol. 64, No. 3, 1988, p. 1009-1016.

Research output: Contribution to journalArticle

Habib, Michael P ; Dunn, A. M. ; Sobonya, Richard E ; Baumgartener, C. C. ; Newell, J. D. ; Halonen, M. / Immunoglobulin E anaphylaxis in rabbits : Mechanisms of pulmonary resistance and compliance changes. In: Journal of Applied Physiology. 1988 ; Vol. 64, No. 3. pp. 1009-1016.
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