Immunoglobulin E and its regulators.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Novel paradigms are emerging in the field of IgE regulation. Gene-environment interactions are increasingly considered to be major determinants of the type and amplitude of allergen-induced antibody responses. At the molecular level, the mechanistic connection between transcription and switching has been strengthened by the recent discovery that class switch recombination requires activation-induced deaminase, a novel RNA editing enzyme. These findings will be critical for our understanding of the mechanisms that determine immunoglobulin isotype expression during immune responses.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume1
Issue number1
StatePublished - Feb 2001

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RNA Editing
Gene-Environment Interaction
Immunoglobulin Isotypes
Allergens
Immunoglobulin E
Genetic Recombination
Antibody Formation
Enzymes
AICDA (activation-induced cytidine deaminase)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immunoglobulin E and its regulators. / Vercelli, Donata.

In: Current Opinion in Allergy and Clinical Immunology, Vol. 1, No. 1, 02.2001, p. 61-65.

Research output: Contribution to journalArticle

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